ArticleRadiology. Artificial intelligence2023
DeePSC: A Deep Learning Model for Automated Diagnosis of Primary Sclerosing Cholangitis at Two-dimensional MR Cholangiopancreatography.
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Article in Radiology. Artificial intelligence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Identification of Primary Sclerosing Cholangitis: ICD-10 Code Validation and Comparison with a Large Language Model Approach.Digestive diseases and sciences · 2026Article
- Artificial intelligence and digital transformation of gastroenterology and hepatology: A critical review of clinical applications and future challenges.World journal of hepatology · 2026Review
- Deep learning models in classifying primary bone tumors and bone infections based on radiographs.NPJ precision oncology · 2025Article
- Primary Sclerosing Cholangitis: Diagnostic Criteria.Tomography (Ann Arbor, Mich.) · 2024Review
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13 authors at 1 institution in 1 country.
Haissam Ragab *From the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0001-8467-6806
Fabian Westhaeusser *From the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0001-9321-5112
Anne ErnstFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).
Jin YamamuraFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0003-3990-5125
Patrick FuhlertFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0001-8480-3705
Marina ZimmermannFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0002-2666-5997
Julia SauerbeckFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0002-2256-9164
Farzad ShenasFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).
Cansu ÖzdenFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).
Anna WeidmannFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).
Gerhard AdamFrom the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0001-7976-3868
Stefan Bonn *From the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).
Christoph Schramm *From the Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (H.R., J.Y., J.S., F.S., C.Ö., A.W., G.A.); Institute of Medical Systems Biology, Center for Biomedical AI, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (F.W., A.E., P.F., M.Z., S.B.); Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M.Z., C.S.); Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany (S.B., C.S.); and Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (C.S.).ORCID 0000-0002-4264-1928
Universität Hamburg · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To develop, train, and validate a multiview deep convolutional neural network (DeePSC) for the automated diagnosis of primary sclerosing cholangitis (PSC) on two-dimensional MR cholangiopancreatography (MRCP) images. Materials and Methods: This retrospective study included two-dimensional MRCP datasets of 342 patients (45 years ± 14 [SD]; 207 male patients) with confirmed diagnosis of PSC and 264 controls (51 years ± 16; 150 male patients). MRCP images were separated into 3-T ( Results: DeePSC achieved an accuracy of 80.5% ± 1.3 (sensitivity, 80.0% ± 1.9; specificity, 81.1% ± 2.7) on the 3-T and 82.6% ± 3.0 (sensitivity, 83.6% ± 1.8; specificity, 80.0% ± 8.9) on the 1.5-T test set and scored even higher on the external test set (accuracy, 92.4% ± 1.1; sensitivity, 100.0% ± 0.0; specificity, 83.5% ± 2.4). DeePSC outperformed radiologists in average prediction accuracy by 5.5 ( Conclusion: Automated classification of PSC-compatible findings based on two-dimensional MRCP was achievable and demonstrated high accuracy on internal and external test sets.
Indexed as
Deep LearningLiver DiseaseMR CholangiopancreatographyMRINeural NetworksPrimary Sclerosing Cholangitis
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