ArticleFrontiers in medicine2023
Medium to long term follow up study of the efficacy of cessation of eye-rubbing to halt progression of keratoconus.
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 13 citations in OpenAlex.
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Trends in the Management of Keratoconus in Australia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Tomographic and Biomechanical Stability of the Non-operated Eye in Asymmetric Keratoconus with Unilateral Intracorneal Ring Segment Implantation.Ophthalmology and therapy · 2026Article
- Evaluating corneal topographic patterns in keratoconic eyes and their association with keratoconus changes over time.International journal of ophthalmology · 2026Article
- Greater exposure to PMScientific reports · 2025Article
- The microenvironment of ocular surface in keratoconus: a systematic review.Eye and vision (London, England) · 2025Review
- Extremely asymmetric ectasia: Tomographically unilateral keratoconus.Acta ophthalmologica · 2025Article
- Keratoconus: The Local Manifestation of a Systemic Disease?Journal of clinical medicine · 2025Review
- Using Artificial Intelligence for an Efficient Prediction of Outcomes of Deep Anterior Lamellar Keratoplasty (DALK) in Advanced Keratoconus.Translational vision science & technology · 2025Article
- Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus.Investigative ophthalmology & visual science · 2025Article
- Mediating roles of corneal biomechanical and topographic parameters in eye rubbing and keratoconus based on the Chinese keratoconus cohort study.Frontiers in bioengineering and biotechnology · 2025Article
- Awareness of Keratoconus Among the Population of Taif City, Saudi Arabia: A Cross-Sectional Study.Cureus · 2024Article
- Eye-Rubbing Detection Using a Smartwatch: A Feasibility Study Demonstrated High Accuracy With Machine Learning.Translational vision science & technology · 2024Article
- Gene‒Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To study the progression of keratoconus after cessation of eye rubbing with a minimum follow up of three-years. Design: Retrospective, monocentric, longitudinal cohort study of keratoconus patients with a minimum of 3 years follow-up. Participants: One hundred fifty three eyes of seventy-seven consecutive patients with keratoconus were included. Methods: Initial examination consisted of anterior and posterior segment evaluation using slit-lamp biomicroscopy. At the initial visit, patients were thoroughly informed of their pathology and instructed to stop rubbing their eyes. Eye rubbing cessation was assessed at all the follow-up visits at 6 months, 1 year, 2 years, 3 years, and yearly afterward. Corneal topography using the Pentacam® (Oculus®, Wetzlar, Germany) was used to obtain maximum and average anterior keratometry readings (Kmax and Kmean), as well as thinnest pachymetry (Pachymin, μm) in both eyes. Main outcome measures: The main outcomes measured were maximum keratometry (Kmax), mean keratometry (Kmean), and thinnest pachymetry (Pachymin) values at various time points to assess for keratoconus progression. Keratoconus progression was defined as a significant augmentation of Kmax (>1D), Kmean (>1D), or significant diminution of Pachymin (>5%) throughout the total follow-up duration. Results: One hundred fifty three eyes of seventy-seven patients (75.3% males) aged 26.4 years old, were followed for an average of 53 months. Over the course of the follow-up, there was no statistically significant variation of ∆Kmax (+0.04 ± 0.87; Conclusion: This study suggests that a significant proportion of keratoconus patients are likely to remain stable if close monitoring and strict ARB cessation are achieved, without the need for further intervention.
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