Evidence map›Paper›PMID 37293160›Full record

ArticleAmerican journal of cancer research2023

Decoding the biological properties and transcriptomic landscapes of human natural killer cells derived from bone marrow and umbilical cord blood.

Baoguo Xie, Leisheng Zhang, Jianhua Gao, Ti'er Wang, Min Liu, Xiaoming Feng, Xianghong Xu, Shixun Ma, Hui Cai, Tiankang Guo and 7 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Baoguo XieReproductive Medicine Center, The First Affiliated Hospital of Hainan Medical University, Key Laboratory of Reproductive Health Diseases Research and Translation (Hainan Medical University), Ministry of Education Haikou 570102, Hainan, China.
Leisheng ZhangKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Jianhua GaoInstitute of Stem Cell, Jiangxi Medical College Shangrao 334000, Jiangxi, China.
Ti'er WangState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020, China.
Min LiuState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020, China.
Xiaoming FengState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Disease, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300020, China.
Xianghong XuKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Shixun MaKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Hui CaiKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Tiankang GuoKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Weibin HuangDepartment of Critical Care Medicine, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China.
Xiaoyan TuDepartment of Critical Care Medicine, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China.
Shuling WangDepartment of Critical Care Medicine, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China.
Hongju YangDivision of Gastroenterology, The First Affiliated Hospital of Kunming Medical University Kunming 650031, Yunnan, China.
Yihu FangInstitute of Stem Cell, Jiangxi Medical College Shangrao 334000, Jiangxi, China.
Feifei LiDepartment of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University Hefei 230032, Anhui, China.
Cunrong ChenDepartment of Critical Care Medicine, Fujian Medical University Union Hospital Fuzhou 350001, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Longitudinal studies have highlighted allogeneic natural killer (NK) cell-based cytotherapy for cancer immunosurveillance and immunotherapy, yet the deficiency of systematic and detailed comparison of NK cells from candidate sources including umbilical cord blood (UC) and bone marrow (BM) largely hinders the large-scale application. Herein, we isolated resident NK cells (rUC-NK, rBM-NK) from mononuclear cells (MNC), and analyzed the corresponding expanded NK cell counterparts (eUC-NK, eBM-NK). Then, the eUC-NK and eBM-NK were turned to multifaceted bioinformatics from the aspects of gene expression profiling and genetic variations. The percentages of total or activated NK cells in rBM-NK group were approximate 2-fold higher over those in the rUC-NK group, respectively. Instead, the proportion of total NK cells in eUC-NK was higher than that in the eBM-NK group, and in particular, the CD25

Indexed as

biological signaturescancer immunotherapyNatural killer cellstranscriptomic characteristicsumbilical cord blood

Identifiers

PMID37293160
PMCPMC10244092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.