Evidence map›Paper›PMID 37293119›Full record

ArticlebioRxiv : the preprint server for biology2023

Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.

Katie Thompson, Will Suber, Rachel Nicholas, David N Arnosti

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Katie ThompsonDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan.
Will SuberDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan.
Rachel NicholasDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan.
David N ArnostiDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan.
Michigan State University · US

Funding

Biochemical, Genomic and Computational Analysis of Transcriptional RepressionR01GM124137 · NIGMS · MICHIGAN STATE UNIVERSITY · PI ARNOSTI, DAVID N · 2017 to 2020
$1.2M
NIGMS NIH HHS R01 GM124137
6 · The paper itself

Abstract

The insulin signaling pathway is evolutionarily conserved throughout metazoans, playing key roles in development, growth, and metabolism. Misregulation of this pathway is associated with a multitude of disease states including diabetes, cancer, and neurodegeneration. Genome-wide association studies indicate that natural variants in putative intronic regulatory elements of the human insulin receptor gene (

Identifiers

PMID37293119
PMCPMC10245858
OpenAlexW4377987711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.