Evidence map›Paper›PMID 37293068›Full record

ArticlebioRxiv : the preprint server for biology2023

Mast cell-derived BH4 is a critical mediator of postoperative pain.

Philipp Starkl, Gustav Jonsson, Tyler Artner, Bruna Lenfers Turnes, Nadine Serhan, Tiago Oliveira, Laura-Marie Gail, Karel Stejskal, Keith M Channon, Thomas Köcher and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 5 countries.

Philipp StarklResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Gustav JonssonInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Tyler ArtnerResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Bruna Lenfers TurnesDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Nadine SerhanToulouse Institute for Infectious and Inflammatory Diseases (Infinity), Inserm UMR1291 CNRS UMR5051, University of Toulouse III, Toulouse, France.
Tiago OliveiraInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Laura-Marie GailDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Karel StejskalInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Keith M ChannonRadcliffe Department of, British Heart Foundation Centre of Research Excellence, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Thomas KöcherVienna BioCenter Core Facilities (VBCF), 1030 Vienna, Austria.
Georg StaryDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Victoria KlangDepartment of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Nicolas GaudenzioToulouse Institute for Infectious and Inflammatory Diseases (Infinity), Inserm UMR1291 CNRS UMR5051, University of Toulouse III, Toulouse, France.
Sylvia KnappResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Clifford J WoolfDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Josef M PenningerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Shane J F CroninInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Institute of Molecular Biotechnology · ATMedical University of Vienna · ATAustrian Academy of Sciences · ATBoston Children's Hospital · USCentre National de la Recherche Scientifique · FRJohn Radcliffe Hospital · GBUniversity of Vienna · ATVienna Biocenter · AT

Funding

Unravelling Mechanisms and Novel Therapeutic Targets for Peripheral Neuropathy and Neuropathic Pain (Diversity Supplement)R35NS105076 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WOOLF, CLIFFORD J · 2018 to 2025
$9.5M
Austrian Science Fund FWF P 31113British Heart Foundation RG/F/22/110085NINDS NIH HHS R35 NS105076
6 · The paper itself

Abstract

Postoperative pain affects most patients after major surgery and can transition to chronic pain. Here, we discovered that postoperative pain hypersensitivity correlated with markedly increased local levels of the metabolite BH4. Gene transcription and reporter mouse analyses after skin injury identified neutrophils, macrophages and mast cells as primary postoperative sources of GTP cyclohydrolase-1 (

Identifiers

PMID37293068
PMCPMC10245978
OpenAlexW4317888782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.