Evidence map›Paper›PMID 37293055›Full record

ArticleResearch square2023

Organ agar serves as physiologically relevant alternative for

Melanie M Pearson, Allyson E Shea, Sapna Pahil, Sara N Smith, Valerie S Forsyth, Harry L T Mobley

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Melanie M PearsonDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4553-3276
Allyson E SheaDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-1329-3888
Sapna PahilDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Sara N SmithDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Valerie S ForsythDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-9195-7665
University of Michigan · US

Funding

Reciprocal Control of Motility and Adherence in UTIR01AI059722 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PEARSON, MELANIE M. · 2005 to 2024
$7.4M
Characterization of pathogen nutrient acquisition and transport systems required during UTIF32AI147527 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHEA, ALLYSON E · 2019 to 2022
$198k
NIAID NIH HHS F32 AI147527NIAID NIH HHS R01 AI059722
6 · The paper itself

Abstract

Animal models for host-microbial interactions have proven valuable, yielding physiologically relevant data that may be otherwise difficult to obtain. Unfortunately, such models are lacking or nonexistent for many microbes. Here, we introduce organ agar, a straightforward method to enable the screening of large mutant libraries while avoiding physiological bottlenecks. We demonstrate that growth defects on organ agar were translatable to colonization deficiencies in a murine model. Specifically, we present a urinary tract infection agar model to interrogate an ordered library of

Identifiers

PMID37293055
PMCPMC10246091
OpenAlexW4377096113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.