Evidence map›Paper›PMID 37293015›Full record

ArticlebioRxiv : the preprint server for biology2023

DNA methylation-environment interactions in the human genome.

Rachel A Johnston, Katherine A Aracena, Luis B Barreiro, Amanda J Lea, Jenny Tung

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Rachel A JohnstonDepartment of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-8965-1162
Katherine A AracenaDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8830-904X
Luis B BarreiroDepartment of Human Genetics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-9456-367X
Amanda J LeaDepartment of Biological Sciences, Vanderbilt University, Nashville, TN 37240, USA.ORCID 0000-0002-8827-2750
Jenny TungDepartment of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.ORCID 0000-0003-0416-2958
Canadian Institute for Advanced Research · CAUniversity of Chicago · USBroad Institute · US

Funding

Early adversity and DNA methylation in a primate model of stress and development.R01HD088558 · NICHD · DUKE UNIVERSITY · PI TUNG, JENNY · 2017 to 2021
$2.0M
Early life environmental effects: molecular mechanisms and inter-individual variationR35GM147267 · NIGMS · VANDERBILT UNIVERSITY · PI Amanda Lea · 2022 to 2026
$2.0M
Quantifying the genome-wide functional consequences of DNA methylation associated with early life adversity.F32HD095616 · NICHD · DUKE UNIVERSITY · PI JOHNSTON, RACHEL ANN · 2018 to 2020
$185k
NICHD NIH HHS F32 HD095616NICHD NIH HHS R01 HD088558
6 · The paper itself

Abstract

Previously we showed that a massively parallel reporter assay, mSTARR-seq, could be used to simultaneously test for both enhancer-like activity and DNA methylation-dependent enhancer activity for millions of loci in a single experiment (Lea

Identifiers

PMID37293015
PMCPMC10245841
OpenAlexW4377140351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.