Evidence map›Paper›PMID 37292956›Full record

ArticleResearch square2023

Neuroticism, Physical Activity, and Cognitive Functioning in a Population-Based Cohort of Older Adults.

Pankaja Desai, Todd Beck, Kristin Krueger, Robert Wilson, Denis Evans, Kumar Rajan

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Pankaja DesaiRush University Medical Center.
Todd BeckRush University Medical Center.
Kristin KruegerRush University Medical Center.
Robert WilsonRush University Medical Center.
Denis EvansRush University Medical Center.
Kumar RajanRush University Medical Center.

Funding

Impact of Neuroinflammation on AD Occurrence: A Bi-Generational Population StudyR01AG073627 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI NEELUM T. AGGARWAL, DENIS A EVANS · 2021 to 2026
$14.0M
Preserving Cognitive Resilience: A Biracial Parent-Offspring Study (18-4674) - Feasibility StudyR01AG058679 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI EVANS, DENIS A, RAJAN, KUMAR B. · 2019 to 2024
$13.8M
Factors Influencing Decline in AD Trends in a Biracial Population StudyRF1AG057532 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2017 to 2017
$1.7M
Nonlinear Models of Cognition Preceding AD in a Biracial Population SampleR01AG051635 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2016 to 2020
$1.5M
NIA NIH HHS R01 AG051635NIA NIH HHS R01 AG058679NIA NIH HHS R01 AG073627NIA NIH HHS RF1 AG057532
6 · The paper itself

Abstract

Background: Little is known about how physical activity influences the relationship between neuroticism and cognitive function and cognitive decline. Methods: Data from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is a population-based cohort study of chronic conditions in older adults. Participants completed in-home interviews cycles of three years from 1993-2012. Mixed effects regression models were conducted to test the associations between physical activity, neuroticism, and the interaction between neuroticism and global cognitive function and global cognitive decline. Stratified mixed effects regression models by physical activity level were conducted to test the associations between neuroticism and global cognitive function and global cognitive decline. Results: A total of 7,685 participants were eligible for this study. Participants were 62% female and 64% African American. We found statistically significant associations for the interaction of medium physical and neuroticism (β = 0.014 (SE = 0.007), p = .037) and the interaction of high physical activity and neuroticism (β = 0.021 (SE = 0.007), p = .003) on global cognitive function at baseline but not for decline over time. Stratified analysis showed that among participants with high physical activity levels, the association between neuroticism and global cognitive decline was statistically significant (β=-0.002 (SE = 0.001), p = .023). Conclusion: Increasing physical activity level benefits the cognitive functioning of individuals with high neuroticism. Interventions should incorporate health behavior change approaches which aim to reduce characteristics of neuroticism.

Indexed as

Cognitive DeclineCognitive FunctionNeuroticismPhysical Activity

Identifiers

PMID37292956
PMCPMC10246268

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.