Evidence map›Paper›PMID 37292954›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Distinct T cell functional profiles in SARS-CoV-2 seropositive and seronegative children associated with endemic human coronavirus cross-reactivity.

Ntombi S B Benede, Marius B Tincho, Avril Walters, Vennesa Subbiah, Amkele Ngomti, Richard Baguma, Claire Butters, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse and 13 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 2 countries.

Ntombi S B BenedeInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Marius B TinchoInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Avril WaltersInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Vennesa SubbiahInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Amkele NgomtiInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Richard BagumaInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Claire ButtersInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Mathilda MennenDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Sango SkelemDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Marguerite AdriaanseDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Strauss van GraanNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.
Sashkia R BallaNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.
Thandeka Moyo-GweteNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.
Penny L MooreInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Maresa BothaDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Lesley WorkmanDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Heather J ZarInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Ntobeko A B NtusiInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Liesl ZühlkeInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Kate WebbSouth African Medical Research Council, Francie Van Zijl Drive, Parow Cape Town, South Africa.
Catherine RiouInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Wendy A BurgersInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Roanne S KeetonInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
University of Cape Town · ZANational Health Laboratory Service · ZASouth African Medical Research Council · ZA

Funding

Contribution of the CD153/CD30 axis to Mycobacterium tuberculosis control in humansR21AI148027 · NIAID · UNIVERSITY OF CAPE TOWN · PI RIOU, CATHERINE · 2019 to 2020
$291k
NIAID NIH HHS R21 AI148027Wellcome Trust
6 · The paper itself

Abstract

SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropositive or seronegative for SARS-CoV-2. SARS-CoV-2-specific CD4+ T cell responses were detectable in 83% of seropositive and 60% of seronegative children. Although the magnitude of the CD4+ T cell response did not differ significantly between the two groups, their functional profiles were distinct, with SARS-CoV-2 seropositive children exhibiting a higher proportion of polyfunctional T cells compared to their seronegative counterparts. The frequency of SARS-CoV-2-specific CD4+ T cells in seronegative children was associated with the endemic human coronavirus (HCoV) HKU1 IgG response. Overall, the presence of SARS-CoV-2-responding T cells in seronegative children may result from cross-reactivity to endemic coronaviruses and could contribute to the relative protection from disease observed in SARS-CoV-2-infected children.

Indexed as

Childrenendemic HCoVIgG responsesPolyfunctional profileSARS-CoV-2T cell response

Identifiers

PMID37292954
PMCPMC10246143
OpenAlexW4377986282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.