Evidence map›Paper›PMID 37292943›Full record

ArticlebioRxiv : the preprint server for biology2023

Co-occurring ripple oscillations facilitate neuronal interactions between cortical locations in humans.

Ilya A Verzhbinsky, Daniel B Rubin, Sophie Kajfez, Yiting Bu, Jessica N Kelemen, Anastasia Kapitonava, Ziv M Williams, Leigh R Hochberg, Sydney S Cash, Eric Halgren

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ilya A VerzhbinskyNeurosciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.
Daniel B RubinCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Sophie KajfezDepartment of Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Yiting BuDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Jessica N KelemenCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Anastasia KapitonavaCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ziv M WilliamsDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114.
Leigh R HochbergCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Sydney S CashCenter for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Eric HalgrenDepartment of Radiology, University of California San Diego, La Jolla, CA 92093, USA.

Funding

Neuroscience Resident Research ProgramR25NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, WILLIAMS, ZIV · 2009 to 2023
$11.8M
TRAINING PROGRAM IN COGNITIVE NEUROSCIENCET32MH020002 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEJNOWSKI, TERRENCE J · 1999 to 2020
$6.1M
Intuitive, complete neural control of tablet computers for communicationU01DC017844 · NIDCD · BROWN UNIVERSITY · PI HOCHBERG, LEIGH R · 2019 to 2025
$4.3M
From ion channel dynamics to human EEG and MEG: multiscale neuronal models validated by human dataRF1MH117155 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAZHENOV, MAKSIM V, CASH, SYDNEY S · 2018 to 2018
$3.7M
High-Bandwidth Wireless Interfaces for Continuous Human Intracortical RecordingUH2NS095548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HOCHBERG, LEIGH R, NURMIKKO, ARTO · 2015 to 2019
$3.7M
NIDCD NIH HHS U01 DC017844NIMH NIH HHS RF1 MH117155NIMH NIH HHS T32 MH020002NINDS NIH HHS R25 NS065743NINDS NIH HHS UH2 NS095548
6 · The paper itself

Abstract

Synchronous bursts of high frequency oscillations ('ripples') are hypothesized to contribute to binding by facilitating integration of neuronal firing across cortical locations. We tested this hypothesis using local field-potentials and single-unit firing from four 96-channel microelectrode arrays in supragranular cortex of 3 patients. Neurons in co-rippling locations showed increased short-latency co-firing, prediction of each-other's firing, and co-participation in neural assemblies. Effects were similar for putative pyramidal and interneurons, during NREM sleep and waking, in temporal and Rolandic cortices, and at distances up to 16mm. Increased co-prediction during co-ripples was maintained when firing-rate changes were equated, and were strongly modulated by ripple phase. Co-ripple enhanced prediction is reciprocal, synergistic with local upstates, and further enhanced when multiple sites co-ripple. Together, these results support the hypothesis that trans-cortical co-ripples increase the integration of neuronal firing of neurons in different cortical locations, and do so in part through phase-modulation rather than unstructured activation.

Identifiers

PMID37292943
PMCPMC10245779

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.