Evidence map›Paper›PMID 37292866›Full record

ArticlebioRxiv : the preprint server for biology2023

Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.

Sonwabile Dzanibe, Aaron J Wilk, Susan Canny, Thanmayi Ranganath, Berenice Alinde, Florian Rubelt, Huang Huang, Mark M Davis, Susan Holmes, Heather B Jaspan and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Sonwabile DzanibeDivision of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Aaron J WilkDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA.
Susan CannyDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA.
Thanmayi RanganathDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA.
Berenice AlindeDivision of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Florian RubeltDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Huang HuangDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.
Susan HolmesDepartment of Statistics, Stanford University, Stanford, CA, USA.
Heather B JaspanDivision of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Catherine A BlishDepartment of Medicine, School of Medicine, Stanford University, Stanford, CA.
Clive M GrayDivision of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Stanford University · USUniversity of Cape Town · ZACenter for Infectious Disease Research · USChan Zuckerberg Initiative (United States) · USHoward Hughes Medical Institute · USSeattle Children's Hospital · US

Funding

Impact of HIV exposure, feeding status, and microbiome on immune ontogeny and vaccine responses in infantsU01AI131302 · NIAID · STANFORD UNIVERSITY · PI BLISH, CATHERINE A, GRAY, CLIVE MAURICE · 2017 to 2021
$2.1M
MECHANISMS LEADING TO ADVERSE BIRTH OUTCOMES IN SOUTH AFRICAN HIV-INFECTED WOMENR01HD102050 · NICHD · UNIVERSITY OF CAPE TOWN · PI GRAY, CLIVE MAURICE, JASPAN, HEATHER BERYL · 2020 to 2024
$1.7M
Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)D71TW012265 · FIC · STELLENBOSCH UNIVERSITY · PI CHAKRABORTY, RANA, GRAY, CLIVE MAURICE · 2022 to 2023
$60k
FIC NIH HHS D71 TW012265NIAID NIH HHS U01 AI131302NICHD NIH HHS R01 HD102050Wellcome Trust
6 · The paper itself

Abstract

While preventing vertical HIV transmission has been very successful, the increasing number of HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Immune developmental differences between iHEU and iHUU remains poorly understood and here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations and differences in the emergence of NK cell populations and T cell memory differentiation between iHEU and iHUU. Specific NK cells observed at birth were also predictive of acellular pertussis and rotavirus vaccine-induced IgG and IgA responses, respectively, at 3 and 9 months of life. T cell receptor Vβ clonotypic diversity was significantly and persistently lower in iHEU preceding the expansion of T cell memory. Our findings show that HIV/ARV exposure disrupts innate and adaptive immunity from birth which may underlie relative vulnerability to infections.

Indexed as

HIV exposureinfant immunityNK cels and antibody responsesT cell receptor

Identifiers

PMID37292866
PMCPMC10245741
OpenAlexW4377608958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.