Evidence map›Paper›PMID 37292845›Full record

ArticlebioRxiv : the preprint server for biology2023

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.

Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Nicholas HoppeDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Simone HarrisonDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Sun-Hee HwangDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ziwei ChenDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Masha KarelinaBiophysics Program, Stanford University, Stanford, CA 94305, USA.
Ishan DeshpandeDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Carl-Mikael SuomivuoriDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Vivek R PalicharlaDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Samuel P BerryDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Philipp TschaiknerInstitute of Molecular Biology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck 6020, Austria.
Dominik RegeleInstitute of Molecular Biology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck 6020, Austria.
Douglas F CoveyDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Eduard StefanInstitute of Molecular Biology and Center for Molecular Biosciences, University of Innsbruck, Innsbruck 6020, Austria.
Debora S MarksDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Jeremy ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158.
Ron O DrorBiophysics Program, Stanford University, Stanford, CA 94305, USA.
Alex S EversDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Saikat MukhopadhyayDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Aashish ManglikDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
University of California, San Francisco · USStanford University · USThe University of Texas Southwestern Medical Center · USUniversität Innsbruck · ATWashington University in St. Louis · USHarvard University · US

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Neuroactive steroids as novel psychiatric treatments: mechanistic studiesP50MH122379 · NIMH · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2021 to 2025
$12.2M
STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0M
Acquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0M
Signaling at the primary cilium in development and diseaseR35GM144136 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Saikat Mukhopadhyay · 2022 to 2026
$1.6M
Discovering the mechanism of GPCR-mediated arrestin stimulation to enable effective drug therapiesR01GM127359 · NIGMS · STANFORD UNIVERSITY · PI DROR, RON · 2018 to 2022
$1.5M
Mechanisms of Smoothened Activation in Hedgehog SignalingR01GM138992 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANGLIK, AASHISH · 2022 to 2025
$1.3M
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
NIGMS NIH HHS R01 GM108799NIGMS NIH HHS R01 GM127359NIGMS NIH HHS R01 GM138992NIGMS NIH HHS R35 GM144136NIGMS NIH HHS T32 GM008284NIGMS NIH HHS U24 GM129541NIH HHS S10 OD020054NIH HHS S10 OD021741NIMH NIH HHS P50 MH122379
6 · The paper itself

Abstract

The orphan G protein-coupled receptor (GPCR) GPR161 is enriched in primary cilia, where it plays a central role in suppressing Hedgehog signaling

Identifiers

PMID37292845
PMCPMC10245861
OpenAlexW4378602390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.