ArticlemedRxiv : the preprint server for health sciences2023
Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry.
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Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
110 authors at 20 institutions in 21 countries.
Burcu F DarstCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jiayi ShenCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ravi K MadduriArgonne National Laboratory, Lemont, IL, USA.
Alexis A RodriguezArgonne National Laboratory, Lemont, IL, USA.
Yukai XiaoArgonne National Laboratory, Lemont, IL, USA.
Xin ShengCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Edward J SaundersThe Institute of Cancer Research, London, UK.
Tokhir DadaevThe Institute of Cancer Research, London, UK.
Mark N BrookThe Institute of Cancer Research, London, UK.
Thomas J HoffmannDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Peggy WanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Lynne WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Ying WangDepartment of Population Science, American Cancer Society, Atlanta, GA, USA.
Johanna SchleutkerInstitute of Biomedicine, University of Turku, Finland.
Robert J MacInnisCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
David E NealNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.
Børge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Sune F NielsenFaculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Judith A ClementsAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
Australian Prostate Cancer BioResource
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Nora PashayanUniversity College London, Department of Applied Health Research, London, UK.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Lorelei A MucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
David J HunterNuffield Department of Population Health, University of Oxford, Oxford, UK.
Kathryn L PenneyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Robert J HamiltonDept. of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Canada.
Marie-Élise ParentEpidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Alicja WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karina D SørensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Edward D YeboahUniversity of Ghana Medical School, Accra, Ghana.
James E MensahUniversity of Ghana Medical School, Accra, Ghana.
Yong-Jie LuCentre for Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK.
Daniel J SchaidDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Stephen N ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Catharine M WestDivision of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.
Christiane MaierHumangenetik Tuebingen, Tuebingen, Germany.
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA.
Géraldine Cancel-TassinCeRePP, Tenon Hospital, Paris, France.
Florence Menegaux"Exposome and Heredity", CESP (UMR 1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France.
Esther M JohnDepartment of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, UK.
Sue A InglesDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ana VegaFundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.
Barry S RosensteinDepartment of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
NC-LA PCaP Investigators
Manolis KogevinasISGlobal, Barcelona, Spain.
Lisa Cannon-AlbrightDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Chad HuffDepartment of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Luc MultignerUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France.
Radka KanevaMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.
Robin J LeachDepartment of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio Texas, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ann W HsingDepartment of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Rick A KittlesDivision of Health Equities, Department of Population Sciences, City of Hope, Duarte, CA, USA.
Adam B MurphyDepartment of Urology, Northwestern University, Chicago, IL, USA.
Christopher J LogothetisThe University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
William B IsaacsJames Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA.
Barbara NemesureDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
Anselm J HennisDepartment of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA.
John CarptenDepartment of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hardev PandhaFaculty of Health and Medical Sciences, The University of Surrey, Guildford, Surrey, UK.
Kim De RuyckGhent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium.
Jianfeng XuProgram for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.
Azad RazackDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Soo-Hwang TeoCancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia.
Canary PASS Investigators
Lisa F NewcombDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jay H FowkeDivision of Epidemiology, Department of Preventive Medicine, The University of Tennessee Health Science Center, TN, USA.
Christine Neslund-DudasDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Benjamin A RybickiDepartment of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.
Marija GamulinDepartment of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
Nawaid UsmaniDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Frank ClaessensMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium.
Manuela GagoDominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.
Jose Esteban CastelaoGenetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain.
Paul A TownsendDivision of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, UK.
Dana C CrawfordCase Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Cleveland, OH, USA.
Gyorgy PetrovicsCenter for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA.
Graham CaseyCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Monique J Roobol109 Department of Urology, Erasmus University Medical Center, Cancer Institute, Rotterdam, The Netherlands.
Jennifer F HuThe University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Stephen K Van Den EedenDivision of Research, Kaiser Permanente, Northern California, Oakland, CA, USA.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Michael B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
John S WitteDepartment of Epidemiology and Population Health, Department of Biomedical Data Science, Stanford Cancer Institute, Stanford, CA, USA.
Rosalind A EelesThe Institute of Cancer Research, Sutton, London, UK.
Zsofia Kote-JaraiThe Institute of Cancer Research, Sutton, London, UK.
Stephen WatyaSchool of Public Health, Makerere University College of Health Sciences, Kampala Uganda.
John M GazianoVA Boston Healthcare System, Boston, MA, USA.
Amy C JusticeVA Connecticut Healthcare System, West Haven, CT, USA.
David V ContiCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christopher A HaimanCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USBrigham and Women's Hospital · USInstitute of Cancer Research · GBManchester Academic Health Science Centre · GBInserm · FRNational Cancer Institute · USThe University of Texas MD Anderson Cancer Center · USUniversity of Cambridge · GBUniversity of Washington · USArgonne National Laboratory · USUniversity of Ghana · GHGerman Cancer Research Center · DEHarvard University · USHenry Ford Hospital · USKaiser Permanente · USMoffitt Cancer Center · USNorthShore University HealthSystem · USNorthwestern University · USOslo University Hospital · NOTranslational Research Institute · AU
Funding
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MResearch on Prostate Cancer in Men of African Ancestry: Defining the Roles of Genetics, Immunity and Stress (RESPOND)U19CA214253 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN · 2018 to 2023
$16.8MEpidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4MPCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4MGenome-wide sequencing of prostate cancer in men of African ancestryR01CA165862 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAIMAN, CHRISTOPHER ALAN, REICH, DAVID E · 2012 to 2016
$3.1MMultiethnic GWAS and TWAS to Inform Risk Prediction for Prostate CancerU01CA257328 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CONTI, DAVID V, HAIMAN, CHRISTOPHER ALAN · 2021 to 2025
$3.1MIntegrating Genomics and Metabolomics to Develop Predictive Models of Prostate Cancer in Multiethnic MenR00CA246063 · NCI · FRED HUTCHINSON CANCER CENTER · PI DARST, BURCU FRANCES · 2022 to 2024
$830kNCI NIH HHS R00 CA246063NCI NIH HHS R01 CA165862NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA257328NCI NIH HHS U19 CA148537NCI NIH HHS U19 CA214253NCI NIH HHS UG1 CA189974
Abstract
Genome-wide polygenic risk scores (GW-PRS) have been reported to have better predictive ability than PRS based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several GW-PRS approaches to a recently developed PRS of 269 established prostate cancer risk variants from multi-ancestry GWAS and fine-mapping studies (PRS
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