Evidence map›Paper›PMID 37292804›Full record

ArticlebioRxiv : the preprint server for biology2023

Tumor Cytokine-Induced Hepatic Gluconeogenesis Contributes to Cancer Cachexia: Insights from Full Body Single Nuclei Sequencing.

Ying Liu, Ezequiel Dantas, Miriam Ferrer, Yifang Liu, Aram Comjean, Emma E Davidson, Yanhui Hu, Marcus D Goncalves, Tobias Janowitz, Norbert Perrimon

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 16 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ying LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Ezequiel DantasDivision of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Miriam FerrerCold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724 USA.
Yifang LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Aram ComjeanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Emma E DavidsonCold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724 USA.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Marcus D GoncalvesDivision of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Tobias JanowitzCold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724 USA.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Harvard University · USCornell University · USHoward Hughes Medical Institute · USNorthwell Health · US

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
CANCAN ? CORNELLOT2CA278685 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2022 to 2023
$657k
Cancer Research UK CGCATF-2021/100026NCI NIH HHS OT2 CA278685NCI NIH HHS P01 CA120964
6 · The paper itself

Abstract

A primary cause of death in cancer patients is cachexia, a wasting syndrome attributed to tumor-induced metabolic dysregulation. Despite the major impact of cachexia on the treatment, quality of life, and survival of cancer patients, relatively little is known about the underlying pathogenic mechanisms. Hyperglycemia detected in glucose tolerance test is one of the earliest metabolic abnormalities observed in cancer patients; however, the pathogenesis by which tumors influence blood sugar levels remains poorly understood. Here, utilizing a

Identifiers

PMID37292804
PMCPMC10245574
OpenAlexW4377029734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.