Evidence map›Paper›PMID 37292803›Full record

ArticleResearch square2023

Pan-cancer transcriptomic analysis of CNS tumor stroma identifies a population of perivascular fibroblasts that predict poor immunotherapy response in glioblastoma patients.

Maksym Zarodniuk, Alexander Steele, Xin Lu, Jun Li, Meenal Datta

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Maksym ZarodniukDepartment of Aerospace and Mechanical Engineering, University of Notre Dame.
Alexander SteeleDepartment of Electrical Engineering, University of Notre Dame.
Xin LuDepartment of Biological Sciences, University of Notre Dame.ORCID 0000-0002-0284-6478
Jun LiDepartment of Applied and Computational Mathematics and Statistics, University of Notre Dame.
Meenal DattaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame.ORCID 0000-0001-5727-8992
University of Notre Dame · US

Funding

Converting Cold to Hot Tumor Microenvironment in Prostate Cancer by Targeting Chromatin EffectorR01CA248033 · NCI · UNIVERSITY OF NOTRE DAME · PI LU, XIN · 2020 to 2024
$1.8M
Targeting abnormal immunomechanics in the glioblastoma microenvironment to improve therapeutic responseK22CA258410 · NCI · UNIVERSITY OF NOTRE DAME · PI DATTA, MEENAL · 2021 to 2023
$573k
NCI NIH HHS K22 CA258410NCI NIH HHS R01 CA248033
6 · The paper itself

Abstract

Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular components contribute to the formation of ECM stroma in central nervous system (CNS) tumors. Here, we undertook a pan-CNS analysis of retrospective gene expression datasets to characterize inter- and intra-tumoral heterogeneity of ECM remodeling signatures in both adult and pediatric CNS disease. We found that CNS lesions - glioblastoma in particular - can be divided into two ECM-based subtypes (ECM

Identifiers

PMID37292803
PMCPMC10246264
OpenAlexW4376604224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.