Evidence map›Paper›PMID 37292800›Full record

ArticleResearch square2023

Glutamic Acid Intake by Formula-Fed Infants: Are Acceptable Daily Intakes Feasible?

Julie A Mennella, Alissa D Smethers, Michelle T Delahanty, Virginia A Stallings, Jillian C Trabulsi

Registry-linked trialOpen access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01700205 (Impact of Diet Composition on Energy Balance and Satiety During Infancy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01700205 nacompletednot on this map

Impact of Diet Composition on Energy Balance and Satiety During Infancy

TypeinterventionalSponsorMonell Chemical Senses CenterRan2012 to 2016Enrolled113ConditionsDevelopmentArmsType of Formula
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Julie A MennellaMonell Chemical Senses Center.
Alissa D SmethersMonell Chemical Senses Center.
Michelle T DelahantyUniversity of Delaware.
Virginia A StallingsChildren's Hospital of Philadelphia.
Jillian C TrabulsiUniversity of Delaware.
Monell Chemical Senses Center · USUniversity of Delaware · USChildren's Hospital of Philadelphia · US

Funding

Impact of diet composition during infancy on energy balance, satiety and growthR01HD072307 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2012 to 2016
$2.7M
Secondary Analyses of RCT Data on Infant Formula and Nutritional ProgrammingR03HD094908 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2018 to 2019
$173k
NICHD NIH HHS R01 HD072307NICHD NIH HHS R03 HD094908
6 · The paper itself

Abstract

purposeThe 2017 European Food Safety Authority (EFSA) recommendation of an acceptable daily intake (ADI) of 30 mg glutamic acid/kg bw/d did not take into consideration the primary energy sources during infancy, including infant formulas. In the present study, we determined total daily intakes of glutamic acid in a contemporary cohort of healthy infants who were fed either cow milk formula (CMF) or extensive protein hydrolysate formulas (EHF); the formulas differed in glutamic acid content (262.4 mg/100ml, CMF; 436.2 mg/100ml, EHF).

methodsThe infants ( CLINICALTRIALS: gov/ as trial registration number NCT01700205 on 3 October 2012.

resultsGlutamic acid intake from formula and other foods was significantly higher in infants fed EHF when compared to CMF. As glutamic acid intake from formula decreased, intake from other nutritional sources steadily increased from 5.5 months. Regardless of formula type, every infant exceeded the ADI of 30 mg/kg bw/d from 0.5 to 12.5 months.

conclusionsFaced with the knowledge that the EFSA health-based guidance value (ADI) was not based on actual intake data and did not account for the primary energy sources during infancy, EFSA may reconsider the scientific literature on growing children's intakes from human milk, infant formula, and the complementary diet to provide parents and health care providers with revised guidelines.

Identifiers

PMID37292800
PMCPMC10246086
OpenAlexW4376867603

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.