Evidence map›Paper›PMID 37292783›Full record

ArticlebioRxiv : the preprint server for biology2023

Metabolic disruption impacts tick fitness and microbial relationships.

Sourabh Samaddar, Anya J O'Neal, Liron Marnin, Agustin Rolandelli, Nisha Singh, Xiaowei Wang, L Rainer Butler, Parisa Rangghran, Hanna J Laukaitis, Francy E Cabrera Paz and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sourabh SamaddarDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Anya J O'NealDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Liron MarninDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Agustin RolandelliDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Nisha SinghDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Xiaowei WangDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
L Rainer ButlerDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Parisa RangghranDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Hanna J LaukaitisDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Francy E Cabrera PazDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Gary M FiskumDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Brian M PolsterDepartment of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
University of Maryland, Baltimore · US

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI UTPAL PAL · 2018 to 2026
$13.5M
Development of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
Systems-Level Research in Microbial PathogenesisT32AI162579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI NICHOLAS H CARBONETTI, Julie Dunning Hotopp · 2022 to 2026
$1.7M
Analysis of Cellular Metabolism using Seahhorse TechnologyS10OD025101 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI VOGEL, STEFANIE N. · 2019 to 2019
$205k
Characterization of a Lipid Receptor in Tick Humoral ImmunityF31AI152215 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI O’NEAL, ANYA JOSEPHINE · 2020 to 2021
$81k
Rab27 in tick extracellular vesicle biogenesisF31AI167471 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BUTLER, LILLIAN RAINER · 2022 to 2023
$77k
NIAID NIH HHS F31 AI152215NIAID NIH HHS F31 AI167471NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI134696NIAID NIH HHS T32 AI162579NIH HHS S10 OD025101
6 · The paper itself

Abstract

Arthropod-borne microbes rely on the metabolic state of a host to cycle between evolutionarily distant species. For instance, arthropod tolerance to infection may be due to redistribution of metabolic resources, often leading to microbial transmission to mammals. Conversely, metabolic alterations aids in pathogen elimination in humans, who do not ordinarily harbor arthropod-borne microbes. To ascertain the effect of metabolism on interspecies relationships, we engineered a system to evaluate glycolysis and oxidative phosphorylation in the tick

Indexed as

Borrelia burgdorferiLyme DiseaseMetabolismRickettsial InfectionTicksVector-Borne Diseases

Identifiers

PMID37292783
PMCPMC10245996
OpenAlexW4378532774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.