Evidence map›Paper›PMID 37292732›Full record

ArticlebioRxiv : the preprint server for biology2023

Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit

Lisa J Funkhouser-Jones, Rui Xu, Georgia Wilke, Yong Fu, Lawrence A Shriefer, Heyde Makimaa, Rachel Rodgers, Elizabeth A Kennedy, Kelli L VanDussen, Thaddeus S Stappenbeck and 2 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lisa J Funkhouser-JonesDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Rui XuDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Georgia WilkeDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Yong FuDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Lawrence A ShrieferDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Heyde MakimaaDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Rachel RodgersDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Elizabeth A KennedyDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Kelli L VanDussenDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Thaddeus S StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Effect of Microbial Metabolites on Growth of CryptosporidiumR01AI145496 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2020 to 2023
$2.7M
DEFINING THE BASIS OF EPITHELIAL DEFECTS IN CROHN'S DISEASE PATIENTSK01DK109081 · NIDDK · WASHINGTON UNIVERSITY · PI VANDUSSEN, KELLI LYNN · 2016 to 2020
$737k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI145496NIDDK NIH HHS K01 DK109081
6 · The paper itself

Abstract

Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children in resource-poor settings. Susceptibility rapidly declines with age, associated with changes in the microbiota. To explore microbial influences on susceptibility, we screened 85 microbiota- associated metabolites enriched in the adult gut for their effects on

Identifiers

PMID37292732
PMCPMC10245909
OpenAlexW4378211511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.