Evidence map›Paper›PMID 37292686›Full record

ArticleResearch square2023

Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution.

Calixto-Hope Lucas, Kanish Mirchia, Kyounghee Seo, Hinda Najem, William Chen, Naomi Zakimi, Abrar Choudhury, S John Liu, Joanna Phillips, Stephen Magill and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Calixto-Hope LucasJohns Hopkins University.ORCID 0000-0002-8347-9592
Kanish MirchiaUniveristy of California San Francisco.ORCID 0000-0002-7371-7059
Kyounghee SeoUniveristy of California San Francisco.
Hinda NajemNorthwestern University.
William ChenUCSF.
Naomi ZakimiUniveristy of California San Francisco.
Abrar ChoudhuryUniversity of California, San Francisco.ORCID 0000-0001-8312-2457
S John LiuUniversity of California San Francisco.ORCID 0000-0003-1042-0191
Joanna PhillipsUCSF.ORCID 0000-0002-3789-8120
Stephen MagillNorthwestern University.
Craig HorbinskiNorthwestern University.ORCID 0000-0001-8340-9992
David SolomonUniversity of California, San Francisco.ORCID 0000-0003-4571-7999
Arie PerryUCSF.ORCID 0000-0002-8300-7261
Harish VasudevanUniversity of California San Francisco.
Amy HeimbergerNorthwestern University.ORCID 0000-0002-9970-8695
David RaleighUniversity of California San Francisco.ORCID 0000-0001-9299-8864
University of California, San Francisco · USUniversidad Católica de Santa Fe · ARUniversity of California System · USJohns Hopkins University · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Atique U. Ahmed · 2018 to 2026
$21.4M
Modulation of Microglia and T Cell Interactions in Malignant GliomaR01CA120813 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, GANESH · 2007 to 2025
$4.7M
Understanding druggable drivers of meningioma tumorigenesisR01CA262311 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RALEIGH, DAVID R · 2021 to 2025
$2.7M
Targeting IDH mutations to improve seizure control in glioma patientsR01NS118039 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HORBINSKI, CRAIG MICHAEL, SWANSON, GEOFFREY T · 2020 to 2024
$2.2M
Interaction between Tissue Factor, Junctional Adhesion Molecule-A, and Integrin B1 to drive self-renewal in glioblastomaR01NS117104 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HORBINSKI, CRAIG MICHAEL, LATHIA, JUSTIN D. · 2020 to 2024
$1.5M
Stinging the Glioma Immune LandscapeR01NS120547 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, ARVIND · 2020 to 2023
$1.1M
Investigating the Regulation and Role of FOXM1 in Aggressive MeningiomaF30CA246808 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOUDHURY, ABRAR · 2020 to 2023
$159k
Development of a molecular diagnostic and prognostic signature for meningiomaF32CA213944 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAGILL, STEPHEN T · 2017 to 2017
$63k
NCI NIH HHS F30 CA246808NCI NIH HHS F32 CA213944NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA221747NCI NIH HHS R01 CA120813NCI NIH HHS R01 CA262311NIGMS NIH HHS T32 GM007618NINDS NIH HHS R01 NS117104NINDS NIH HHS R01 NS118039NINDS NIH HHS R01 NS120547
6 · The paper itself

Abstract

Intratumor heterogeneity underlies cancer evolution and treatment resistance

Identifiers

PMID37292686
PMCPMC10246120
OpenAlexW4376604005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.