Evidence map›Paper›PMID 37292671›Full record

ArticlebioRxiv : the preprint server for biology2023

Irina S Abaeva, Yani Arhab, Anna Miścicka, Christopher U T Hellen, Tatyana V Pestova

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Irina S AbaevaDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Yani ArhabDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Anna MiścickaDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Christopher U T HellenDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Tatyana V PestovaDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
SUNY Downstate Health Sciences University · US

Funding

Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality controlR35GM122602 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI TATYANA V PESTOVA · 2017 to 2026
$4.8M
Mechanisms of SARS-CoV2 translation initiation and shut-off of cellular protein synthesisR21AI166944 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI HELLEN, CHRISTOPHER ULRICH TRISTRAM, PESTOVA, TATYANA V · 2022 to 2023
$446k
NIAID NIH HHS R21 AI166944NIGMS NIH HHS R35 GM122602
6 · The paper itself

Abstract

SARS CoV-2 nonstructural protein 1 (Nsp1) is the major pathogenesis factor that inhibits host translation using a dual strategy of impairing initiation and inducing endonucleolytic cleavage of cellular mRNAs. To investigate the mechanism of cleavage, we reconstituted it

Indexed as

40S ribosomal subuniteIF3geukaryotic translation initiationmRNA cleavageSARS CoV-2 Nsp1

Identifiers

PMID37292671
PMCPMC10245999
OpenAlexW4378373216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.