Evidence map›Paper›PMID 37292656›Full record

ArticleResearch square2023

Generalizable neuromarker for autism spectrum disorder across imaging sites and developmental stages: A multi-site study.

Takashi Itahashi, Ayumu Yamashita, Yuji Takahara, Noriaki Yahata, Yuta Y Aoki, Junya Fujino, Yujiro Yoshihara, Motoaki Nakamura, Ryuta Aoki, Haruhisa Ohta and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 1 country.

Takashi ItahashiMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Ayumu YamashitaBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Yuji TakaharaBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Noriaki YahataBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Yuta Y AokiMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Junya FujinoMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Yujiro YoshiharaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Motoaki NakamuraMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Ryuta AokiMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Haruhisa OhtaMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Yuki SakaiBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Masahiro TakamuraDepartment of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
Naho IchikawaDepartment of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
Go OkadaDepartment of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
Naohiro OkadaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Saori C TanakaBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Hiroshi ImamizuBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Nobumasa KatoMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Yasumasa OkamotoDepartment of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
Hidehiko TakahashiDepartment of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Mitsuo KawatoBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Okito YamashitaBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan.
Ryu-Ichiro HashimotoMedical Institute of Developmental Disabilities Research, Showa University, Tokyo, Japan.
Showa University · JPAdvanced Telecommunications Research Institute International · JPHiroshima University · JPThe University of Tokyo · JPKyoto University · JPNational Institutes for Quantum Science and Technology · JPTokyo Medical and Dental University · JP

Funding

Translational Developmental Neuroscience of AutismK23MH087770 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DI MARTINO, ADRIANA · 2010 to 2013
$644k
Enhancing the Autism Brain Imaging Data Exchange to Define the Autism ConnectomeR21MH107045 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DI MARTINO, ADRIANA · 2015 to 2016
$479k
Enhancement of the 1000 Functional Connectome ProjectR03MH096321 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI BISWAL, BHARAT BHUSAN, MILHAM, MICHAEL PETER · 2012 to 2013
$158k
NIMH NIH HHS K23 MH087770NIMH NIH HHS R03 MH096321NIMH NIH HHS R21 MH107045
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a lifelong condition, and its underlying biological mechanisms remain elusive. The complexity of various factors, including inter-site and development-related differences, makes it challenging to develop generalizable neuroimaging-based biomarkers for ASD. This study used a large-scale, multi-site dataset of 730 Japanese adults to develop a generalizable neuromarker for ASD across independent sites and different developmental stages. Our adult ASD neuromarker achieved successful generalization for the US and Belgium adults and Japanese adults. The neuromarker demonstrated significant generalization for children and adolescents. We identified 141 functional connections (FCs) important for discriminating individuals with ASD from TDCs. Finally, we mapped schizophrenia (SCZ) and major depressive disorder (MDD) onto the biological axis defined by the neuromarker and explored the biological continuity of ASD with SCZ and MDD. We observed that SCZ, but not MDD, was located proximate to ASD on the biological dimension defined by the ASD neuromarker. The successful generalization in multifarious datasets and the observed relations of ASD with SCZ on the biological dimensions provide new insights for a deeper understanding of ASD.

Identifiers

PMID37292656
PMCPMC10246271
OpenAlexW4376618112

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.