Evidence map›Paper›PMID 37292645›Full record

ArticleResearch square2023

Radiomic tractometry: a rich and tract-specific class of imaging biomarkers for neuroscience and medical applications.

Peter Neher, Dusan Hirjak, Klaus Maier-Hein

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Peter NeherDivision of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.
Dusan HirjakDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Klaus Maier-HeinDivision of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Tract-specific microstructural analysis of the brain white matter using diffusion MRI is a driver for neuroscientific discovery with a wide range of applications. Current analysis pipelines have conceptual limitations that narrow their applicability and hamper subject-level analysis and predictions. Radiomic tractometry (RadTract) improves upon that, enabling the extraction and analysis of comprehensive and highly informative microstructural feature sets where previous approaches were restricted to bare summary statistics. We demonstrate the added value in a series of neuroscientific applications, including diagnostic tasks as well as the prediction of demographic and clinical measures across various datasets. Being published as an open and easy-to-use Python package, RadTract could spark the establishment of a new generation of tract-specific imaging biomarkers, with direct benefits for a range of applications from basic neuroscience to medical research.

Identifiers

PMID37292645
PMCPMC10246281

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.