Evidence map›Paper›PMID 37292598›Full record

ArticlebioRxiv : the preprint server for biology2023

Association of genetic variation in

Hao Yu, Anas M Khanshour, Aki Ushiki, Nao Otomo, Yoshinao Koike, Elisabet Einarsdottir, Yanhui Fan, Lilian Antunes, Yared H Kidane, Reuel Cornelia and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 5 countries.

Hao YuCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Anas M KhanshourCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Aki UshikiDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Nao OtomoLaboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, JP.
Yoshinao KoikeLaboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, JP.
Elisabet EinarsdottirScience for Life Laboratory, Department of Gene Technology, KTH-Royal Institute of Technology, Solna, SE.
Yanhui FanSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, CN.
Lilian AntunesDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Yared H KidaneCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Reuel CorneliaCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Rory ShengDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Yichi ZhangDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Jimin PeiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nick V GrishinDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bret M EversDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jason Pui Yin CheungDepartment of Orthopaedics and Traumatology LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, CN.
John A HerringDepartment of Orthopedic Surgery, Scottish Rite for Children, Dallas, TX, USA.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, JP.
You-Qiang SongSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, CN.
Christina A GurnettDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Paul GerdhemDepartment of Clinical Science, Intervention & Technology (CLINTEC), Karolinska Institutet, Stockholm, Uppsala University, Uppsala, SE.
Shiro IkegawaLaboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, JP.
Jonathan J RiosCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.
Nadav AhituvDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Carol A WiseCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX, USA.ORCID 0000-0002-6790-2194
Texas Scottish Rite Hospital for Children · USRIKEN Center for Integrative Medical Sciences · JPUniversity of California, San Francisco · USChinese University of Hong Kong · HKThe University of Texas Southwestern Medical Center · USWashington University in St. Louis · USScience for Life Laboratory · SEUppsala University · SE

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Non-coding/epigenetic regulationP01HD084387 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Nadav Ahituv, LILIANNA SOLNICAKREZEL · 2016 to 2026
$14.2M
Genetic Risk Factors for Severe ScoliosisR01AR067715 · NIAMS · WASHINGTON UNIVERSITY · PI DOBBS, MATTHEW BARRETT, GURNETT, CHRISTINA · 2015 to 2024
$6.0M
Computational analysis of proteinsR35GM127390 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI GRISHIN, NICK V. · 2018 to 2022
$1.5M
NIAMS NIH HHS R01 AR067715NICHD NIH HHS P01 HD084387NICHD NIH HHS P50 HD103525NIGMS NIH HHS R35 GM127390
6 · The paper itself

Abstract

Adolescent idiopathic scoliosis (AIS) is a common and progressive spinal deformity in children that exhibits striking sexual dimorphism, with girls at more than five-fold greater risk of severe disease compared to boys. Despite its medical impact, the molecular mechanisms that drive AIS are largely unknown. We previously defined a female-specific AIS genetic risk locus in an enhancer near the

Identifiers

PMID37292598
PMCPMC10245954
OpenAlexW4378555588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.