Evidence map›Paper›PMID 37292594›Full record

ArticlebioRxiv : the preprint server for biology2023

Dynamic nuclear polarization illuminates key protein-lipid interactions in the native bacterial cell envelope.

James E Kent, Bryce E Ackermann, Galia T Debelouchina, Francesca M Marassi

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

James E KentSanford Burnham Prebys Medical Discovery Institute, La Jolla CA, 92037, USA.
Bryce E AckermannDepartment Chemistry and Biochemistry, University of California San Diego, La Jolla CA, 92093, USA.
Galia T DebelouchinaDepartment Chemistry and Biochemistry, University of California San Diego, La Jolla CA, 92093, USA.
Francesca M MarassiSanford Burnham Prebys Medical Discovery Institute, La Jolla CA, 92037, USA.
Sanford Burnham Prebys Medical Discovery Institute · USUniversity of California San Diego · US

Funding

Membrane Protein Effectors of Pathogen Interactions With HostR35GM118186 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Francesca M Marassi · 2016 to 2026
$8.5M
Structural biology of chromatin in vitro and in cellsR35GM138382 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina · 2020 to 2026
$2.8M
NIGMS NIH HHS R35 GM118186NIGMS NIH HHS R35 GM138382
6 · The paper itself

Abstract

Elucidating the structure and interactions of proteins in native environments has become a fundamental goal of structural biology. Nuclear magnetic resonance (NMR) spectroscopy is well suited for this task but often suffers from low sensitivity, especially in complex biological settings. Here, we use a sensitivity-enhancement technique called dynamic nuclear polarization (DNP) to overcome this challenge. We apply DNP to capture the membrane interactions of the outer membrane protein Ail, a key component of the host invasion pathway of

Identifiers

PMID37292594
PMCPMC10245764
OpenAlexW4377098398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.