Evidence map›Paper›PMID 37292347›Full record

ArticleHeliyon2023

Comparison of video-assisted pleurectomy/decortication surgery plus hyperthermic intrathoracic chemotherapy with VATS talc pleurodesis for the treatment of malignant pleural mesothelioma: A pilot study.

Marcello Migliore, Maria Fiore, Tommaso Filippini, Rosario Tumino, Mara Sabbioni, Corrado Spatola, Riccardo Polosa, Paolo Vigneri, Marco Nardini, Sergio Castorina and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Present and future of cytoreductive surgery and hyperthermic intrathoracic chemotherapy for pleural metastases: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Marcello MiglioreMinimally Invasive Thoracic Surgery and New Technologies University Hospital of Catania, Department of General Surgery and Medical Specialties, University of Catania, Catania, Italy.
Maria FioreDepartment of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.
Tommaso FilippiniEnvironmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Rosario TuminoCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy.
Mara SabbioniItalian National Asbestos Organization, Rome, Italy.
Corrado SpatolaRadiotherapy Unit, University of Catania, Catania, Italy.
Riccardo PolosaGeneral Medicine, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy.
Paolo VigneriCenter of Oncology and Hematology, Department of Clinical & Experimental Medicine University of Catania, Catania, Italy.
Marco NardiniDepartment of Thoracic Surgery, St. James University Hospital, London, UK.
Sergio CastorinaGeneral and Thoracic Surgery, Morgagni Policlinic Hospital, Catania, Italy.
Francesco BasileGeneral Surgery, University Hospital of Catania, Department of General Surgery and Medical Specialties, University of Catania, Catania, Italy.
Margherita FerranteDepartment of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.
University of Catania Study Group of Malignant Pleural Mesotelioma
University of Catania · ITKing Faisal Specialist Hospital & Research Centre · SASt James's University Hospital · GBUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperthermic intrathoracic chemotherapy (HITHOC) adjunct to surgery for Malignant Pleural Mesothelioma (MPM) has no definite role. The primary objective of this pilot-trial was to evaluate the feasibility for future large studies. The study design was a prospective randomized three-centric pilot trial. We recruited patients diagnosed with MPM and prospectively assigned them to two groups: Group A: Video Assisted Thoracic Surgery (VATS) talc pleurodesis or Group B: Video-assisted P/D plus HITHOC. From November-2011 to July-2017 24 males and 3 females, with a median age of 68-years were enrolled (recruitment rate 5 patients/year). Preoperative stage was I-II, and 18 had epithelioid type. 14 patients were in the Group A. Operative mortality was 0. Follow-up ranged 6-80 months. The median overall survival time started to diverge at 20 months, being 19 months (95% CI 12-25) in Group A and 28 months (95% CI 0-56) in Group B. Survival rate for the epithelioid type was 15 months (95% CI 0-34) in Group A and 45 months (95% CI 0-107) in the Group B. These findings suggest that video-assisted P/D plus HITHOC may improve survival time in MPM patients undergoing surgical treatment and support the need for a larger multicenter randomized clinical trial.

Indexed as

Debulking surgeryHyperthermic intrathoracic chemotherapy (HITHOC)Malignant pleural mesotheliomaPleurectomy/decorticationVideo assisted thoracic surgery (VATS)

Identifiers

PMID37292347
PMCPMC10245266
OpenAlexW4378212308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.