Evidence map›Paper›PMID 37292287›Full record

ArticleHeliyon2023

Teklie Mengie Ayele, Endeshaw Chekol Abebe, Zelalem Tilahun Muche, Melaku Mekonnen Agidew, Yohannes Shumet Yimer, Getu Tesfaw Addis, Nega Dagnaw Baye, Achenef Bogale Kassie, Muluken Adela Alemu, Tesfagegn Gobezie Yiblet and 5 more

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Sustainable Utilization of Agricultural By-Products:Journal of pharmacopuncture · 2025
    Article
  3. Antidiarrheal Activities of the Methanol Leaf Extracts ofJournal of experimental pharmacology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Teklie Mengie AyeleDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Endeshaw Chekol AbebeDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Zelalem Tilahun MucheDepartment of Medical Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Melaku Mekonnen AgidewDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Yohannes Shumet YimerDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Getu Tesfaw AddisDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Nega Dagnaw BayeDepartment of Human Anatomy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Achenef Bogale KassieDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Muluken Adela AlemuDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Tesfagegn Gobezie YibletDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Gebrehiwot Ayalew TirunehDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Samuel Berihun DagnewDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Tilaye Arega MogesDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Tesfaye Yimer TadesseDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Amien Ewnetei ZelalemDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Debre Tabor University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Even though numerous conventional anti-diarrheal agents are available, the inherent toxicities of the drugs urge the search for alternative drugs that are safe and effective. Objective: To evaluate the Materials and methods: The Results: A significant (p˂0.01) reduction in the frequency of wet stools and watery content of diarrhea, intestinal motility, intestinal fluid accumulation, and delaying the onset of diarrhea as compared with controls were observed in mice treated with 200 mg/kg and 400 mg/kg methanol crude extract. However the effect increased dose-dependently, and the 400 mg/kg methanol crude extract produced a comparable effect with the standard drug in all models. Amongst the solvent fractions, n-BF significantly delayed the time of diarrheal onset and reduced the frequency of defecation, and intestinal motility at doses of 200 mg/kg and 400 mg/kg. Furthermore, the maximum percentage inhibition of intestinal fluid accumulation was observed in mice treated with 400 mg/kg n-butanol extract (p˂0.01; 61.05%). Conclusions:

Indexed as

Anti enteropoolingCastor oil-induced diarrheaIntestinal transitRhamnus prinoides

Identifiers

PMID37292287
PMCPMC10245265
OpenAlexW4378648199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.