Evidence map›Paper›PMID 37292170›Full record

ArticleInternational journal of bioprinting2023

Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle.

Zewei Sun, Xianlin Yue, Lei Liu, Ying Li, Jie Cui, Dong Li, Lee Weiss, Phil Campbell, Yanling Mu, Johnny Huard and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Zewei SunShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Xianlin YueShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Lei LiuShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Ying LiShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Jie CuiShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Dong LiCryomedicine Lab, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Lee WeissThe Robotics Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Phil CampbellThe Robotics Institute, Carnegie Mellon University, Pittsburgh, PA, USA.
Yanling MuShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Johnny HuardCenter for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, CO, USA.
Xiaodong MuShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Shandong First Medical University · CNCarnegie Mellon University · USSteadman Philippon Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

299In Duchenne muscular dystrophy, dystrophic muscle phenotypes are closely associated with the exhaustion of muscle stem cells. Transplantation of muscle stem cells has been widely studied for improving muscle regeneration, but poor cell survival and self-renewal, rapid loss of stemness, and limited dispersion of grafted cells following transplantation have collectively hindered the overall success of this strategy. Optimized mechanisms for maintaining and improving stem cell function are naturally present in the microenvironment of the stem cell niche in healthy muscles. Therefore, one logical strategy toward improving stem cell function and efficiency of stem cell transplantation in diseased muscles would be the establishment of a microenvironment mimicking some key aspects of healthy native stem cell niches. Here, we applied inkjet-based bioprinting technology to engineer a mimicked artificial stem cell niche in dystrophic muscle, comprising stem cell niche regulating factors (Notch activator DLL1) bioprinted onto 3D DermaMatrix construct. The recombinant DLL1 protein, DLL1 (mouse): Fc (human) (rec), was applied here as the Notch activator. Bioprinted DermaMatrix construct was seeded with muscle stem cells

Indexed as

Muscle dystrophyMuscle stem cellNotch signalingStem cell niche

Identifiers

PMID37292170
PMCPMC10244892
OpenAlexW4328052782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.