Evidence map›Paper›PMID 37291802›Full record

ArticleCell transplantation

Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation Injury.

Ruoyu Guan, Mengxue Pan, Xiaoya Xu, Lixia Du, Xinxin Rao, Guoxiang Fu, Tao Lv, Long Zhang, Yuanchuang Li, Peiyuan Tang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Ruoyu GuanInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Mengxue PanInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Xiaoya XuInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Lixia DuDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Xinxin RaoInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Guoxiang FuInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Tao LvDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Long ZhangDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.ORCID 0000-0003-2477-4417
Yuanchuang LiInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Peiyuan TangInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Yi ZhouInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Yanqing WangDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Zhen ZhangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Jianjun GaoInstitute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Hong ZhouDepartment of Immunology, Anhui Medical University, Hefei, China.
Wenli MiDepartment of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Guoqiang HuaDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial regeneration is critical for barrier maintenance and organ function after intestinal radiation injury. Accumulating evidence indicates that the interleukin family members play critical roles in intestinal stem-cell-mediated epithelial regeneration. However, little is known about the relationship between interleukin 33 (IL-33)/ST2 axis and intestinal regeneration after radiation injury. We demonstrate here that IL-33 expression significantly increased after radiation treatment. Deficiency of IL-33/ST2 promotes intestinal epithelial regeneration, resulting in a reduction of mortality during radiation-induced intestine injury. Using

Indexed as

Interleukin-33Radiation InjuriesHumansInterleukin-1 Receptor-Like 1 ProteinIntestinesStem CellsTransforming Growth Factor betaInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Transforming Growth Factor betaGI syndromeIL-33intestinal stem cellsradiationregeneration

Identifiers

PMID37291802
PMCPMC10272662
OpenAlexW4379967797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.