ArticleGenome biology2023
Protein length distribution is remarkably uniform across the tree of life.
Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed.
- Unspecific Molecular Adsorption (UMA) Sample Preparation Method for Bottom-up and Whole Protein Analysis: The Foundation.Proteomics · 2026Article
- RPL41 stabilizes ribosome dynamics and supports long-protein homeostasis in mammals.Nucleic acids research · 2026Article
- Replication-transcription collisions impose DNA strand-specific constraints on gene length in bacteria.PLoS genetics · 2026Article
- Foldify: Web Application for Protein Structure Prediction.Journal of chemical information and modeling · 2026Article
- A Length-Adaptive LLM-Enhanced Method for Drug-Target Interaction Prediction.International journal of molecular sciences · 2026Article
- Mimetics of in-cell and subcellular crowding and solvation for protein folding.Biochemical Society transactions · 2026Review
- Going beyond size: exploring the metabolic burden inSynthetic biology (Oxford, England) · 2026Article
- BBATProt: a framework predicting biological function with enhanced feature extraction via interpretable deep learning.Briefings in bioinformatics · 2025Article
- Enzyme miniaturization: Revolutionizing future biocatalysts.Biotechnology advances · 2025Review
- Exploration of bioactive variants of the BMP7-derived p[63-82] peptide for ameliorating the OA-associated chondrocyte phenotype.Arthritis research & therapy · 2025Article
- SuperMetal: a generative AI framework for rapid and precise metal ion location prediction in proteins.Journal of cheminformatics · 2025Article
- Annotation matters: the effect of structural gene annotation on orthology inference.Bioinformatics (Oxford, England) · 2025Article
- NeuroScale: evolutional scale-based protein language models enable prediction of neuropeptides.BMC biology · 2025Article
- An algorithmic constraint at the transition to complex life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unified Deep Learning of Molecular and Protein Language Representations with T5ProtChem.Journal of chemical information and modeling · 2025Article
- Quantifying the evolutionary paths to endomembranes.Cell reports · 2025Article
- The emergence of eukaryotes as an evolutionary algorithmic phase transition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microproteins in cancer: identification, biological functions, and clinical implications.Trends in genetics : TIG · 2025Review
- Quality assessment of gene repertoire annotations with OMArk.Nature biotechnology · 2025Article
- Dispensable genome and segmental duplications drive the genome plasticity inFrontiers in fungal biology · 2025Article
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4 authors.
Funding
Abstract
backgroundIn every living species, the function of a protein depends on its organization of structural domains, and the length of a protein is a direct reflection of this. Because every species evolved under different evolutionary pressures, the protein length distribution, much like other genomic features, is expected to vary across species but has so far been scarcely studied.
resultsHere we evaluate this diversity by comparing protein length distribution across 2326 species (1688 bacteria, 153 archaea, and 485 eukaryotes). We find that proteins tend to be on average slightly longer in eukaryotes than in bacteria or archaea, but that the variation of length distribution across species is low, especially compared to the variation of other genomic features (genome size, number of proteins, gene length, GC content, isoelectric points of proteins). Moreover, most cases of atypical protein length distribution appear to be due to artifactual gene annotation, suggesting the actual variation of protein length distribution across species is even smaller.
conclusionsThese results open the way for developing a genome annotation quality metric based on protein length distribution to complement conventional quality measures. Overall, our findings show that protein length distribution between living species is more uniform than previously thought. Furthermore, we also provide evidence for a universal selection on protein length, yet its mechanism and fitness effect remain intriguing open questions.
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