Evidence map›Paper›PMID 37291634›Full record

ArticleWorld journal of surgical oncology2023

High preoperative CEA and systemic inflammation response index (C-SIRI) predict unfavorable survival of resectable colorectal cancer.

Hao Cai, Yu Chen, Qiao Zhang, Yang Liu, HouJun Jia

Abstract read
PubMed Full text at PMC Publisher
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Article in World journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
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21citing papers in PubMed, 4 pooled it
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  5. Comparison of inflammation-based biomarkers in metastatic testicular cancer at initial diagnosis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026
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  9. Evidence for chronic inflammation in cats with cardiomyopathies.Journal of feline medicine and surgery · 2025
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hao CaiDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Medical College Road, Yuzhong District, Chongqing, 400016, China.
Yu ChenDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Medical College Road, Yuzhong District, Chongqing, 400016, China.
Qiao ZhangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Medical College Road, Yuzhong District, Chongqing, 400016, China.
Yang LiuDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Medical College Road, Yuzhong District, Chongqing, 400016, China.
HouJun JiaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1, Medical College Road, Yuzhong District, Chongqing, 400016, China. 13908329596@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCEA and systemic inflammation were reported to correlate with proliferation, invasion, and metastasis of colorectal cancer. This study investigated the prognostic significance of the preoperative CEA and systemic inflammation response index (C-SIRI) in patients with resectable colorectal cancer.

methodsTwo hundred seventeen CRC patients were recruited from Chongqing Medical University, the first affiliated hospital, between January 2015 and December 2017. Baseline characteristics, preoperative CEA level, and peripheral monocyte, neutrophil, and lymphocyte counts were retrospectively reviewed. The optimal cutoff value for SIRI was defined as 1.1, and for CEA, the best cutoff values were 4.1 ng/l and 13.0 ng/l. Patients with low levels of CEA (< 4.1 ng/l) and SIRI (< 1.1) were assigned a value of 0, those with high levels of CEA (≥ 13.0 ng/l) and SIRI (≥ 1.1) were assigned a value of 3, and those with CEA (4.1-13.0 ng/l) and SIRI (≥ 1.1), CEA (≥ 13.0 ng/l), and SIRI (< 1.1) were assigned a value of 2. Those with CEA (< 4.1 ng/l) and SIRI (≥ 1.1) and CEA (4.1-13.0 ng/l) and SIRI (< 1.1) were assigned a value of 1. The prognostic value was assessed based on univariate and multivariate survival analysis.

resultsPreoperative C-SIRI was statistically correlated with gender, site, stage, CEA, OPNI, NLR, PLR, and MLR. However, no difference was observed between C-SIRI and age, BMI, family history of cancer, adjuvant therapy, and AGR groups. Among these indicators, the correlation between PLR and NLR is the strongest. In addition, high preoperative C-SIRI was significantly correlated with poorer overall survival (OS) (HR: 2.782, 95% CI: 1.630-4.746, P < 0.001) based on univariate survival analysis. Moreover, it remained an independent predictor for OS (HR: 2.563, 95% CI: 1.419-4.628, p = 0.002) in multivariate Cox regression analysis.

conclusionOur study showed that preoperative C-SIRI could serve as a significant prognostic biomarker in patients with resectable colorectal cancer.

Indexed as

Colorectal NeoplasmsHumansInflammationPrognosisRetrospective StudiesSurvival AnalysisCarcinoembryonic antigenColorectal cancerPrognosisSystemic inflammation response index

Identifiers

PMID37291634
PMCPMC10251701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.