ArticleBMC psychiatry2023
The lived experience of clozapine discontinuation in patients and carers following suspected clozapine-induced neutropenia.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Case Report: Voglibose-induced persistent leukopenia in a patient with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Low awareness of clozapine-induced agranulocytosis in a mixed-method survey of 354 patients and carers.Schizophrenia (Heidelberg, Germany) · 2025Article
- Genetic identification of undiagnosed benign ethnic neutropenia in patients receiving clozapine treatment.The British journal of psychiatry : the journal of mental science · 2025Article
- Understanding clozapine-related blood dyscrasias. Developments, genetics, ethnicity and disparity: it's a CIN.BJPsych bulletin · 2025Review
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClozapine is the treatment of choice in refractory psychosis. In most countries, clozapine must be stopped indefinitely if white blood cells fall below a defined threshold during routine monitoring. Despite evidence of severe adverse consequences of clozapine discontinuation, published accounts on the lived experiences and perspectives of patients and carers are scarce.
methodWe completed semi-structured interviews with patients (n = 4) and family carers (n = 4) on experiences of clozapine cessation following suspected drug-induced neutropenia. Interviews were audio-recorded, transcribed and analysed thematically.
resultsThe two overarching themes comprised:(i) stress of clozapine below threshold neutrophil results and (ii) patient and carer priorities.
conclusionsThere is a suggested need for evidence-based pharmacological and psychological approaches to support patients and carers after clozapine cessation. Such approaches will minimise the potentially negative physical and emotional sequela in the aftermath of a below threshold neutrophil result and reduce the likelihood of experiencing additional health and social inequalities after clozapine discontinuation.
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Registered trials
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