ArticleNature plants2023
The SnRK2.3-AREB1-TST1/2 cascade activated by cytosolic glucose regulates sugar accumulation across tonoplasts in apple and tomato.
Article in Nature plants, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- Integrated transcriptome-metabolome analyses reveal regulatory networks underlying soluble solids accumulation in Capsicum chinense fruits.The Plant journal : for cell and molecular biology · 2026Article
- FvMAPK6-Mediated FvMYB44s/FvSWEET1 Dual-Layer Regulation Modulates Sugar Accumulation in Strawberry Fruit, With FvSPS3 Enabling Quality-Yield Balance.Plant biotechnology journal · 2026Article
- Integrated metabolomics and transcriptomics reveal sugar metabolism associated with cold tolerance in chrysanthemum.BMC plant biology · 2026Article
- The MdICE1/MdFAMA-MdTYDC Transcriptional Module Confers Cold Tolerance by Regulating Dopamine Metabolism in Apple.Plant biotechnology journal · 2026Article
- Salt-stress-induced tomato sweetening involves an SlSnRK2.6-SlZHD8 sugar accumulation cascade triggered by root-derived abscisic acid.The EMBO journal · 2026Article
- VvMYB44-VvERF045 complex is involved in abscisic acid-induced sugar accumulation by activatingHorticulture research · 2026Article
- ATAC-Seq and RNA-Seq Integration Reveals Chromatin Accessibility and Transcriptional Dynamics During Fruit Color Development in Mulberry.International journal of molecular sciences · 2026Article
- Research progress on sucrose accumulation characteristics and their molecular regulatory networks in the fruits of fruit trees.Frontiers in plant science · 2026Review
- The genomic design of fruit metabolomes.Plant communications · 2025Review
- TheHorticulture research · 2025Article
- ABA promotes fatty acid biosynthesis and transport to boost arbuscular mycorrhizal symbiosis in apple roots.Plant communications · 2025Article
- The MdHB7L-MdICE1L-MdHOS1 Module Fine-Tunes Apple Cold Response via CBF-Dependent and CBF-Independent Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- How vacuolar sugar transporters evolve and control cellular sugar homeostasis, organ development and crop yield.Nature plants · 2025Review
- Tonoplast sugar transporters coordinately regulate tomato fruit development and quality.Plant communications · 2025Article
- Major Facilitator Superfamily transporters balance sugar metabolism in peach.Plant physiology · 2025Article
- CBL1/CIPK23 phosphorylates tonoplast sugar transporter TST2 to enhance sugar accumulation in sweet orange (Citrus sinensis).Journal of integrative plant biology · 2025Article
- Article
- Sugar transporters: mediators of carbon flow between plants and microbes.Frontiers in plant science · 2025Review
- Apple vacuolar sugar transporters regulated by MdDREB2A enhance drought resistance by promoting accumulation of soluble sugars and activating ABA signaling.Horticulture research · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soluble sugars are the core components of fruit quality, and the degree of sugar accumulation is largely determined by tonoplast-localized sugar transporters. We previously showed that two classes of tonoplast sugar transporters, MdERDL6 and MdTST1/2, coordinately regulate sugar accumulation in vacuoles. However, the mechanism underlying this coordination remains unknown. Here we discovered that two transcription factors, MdAREB1.1/1.2, regulate MdTST1/2 expression by binding their promoters in apple. The enhanced MdAREB1.1/1.2 expression in MdERDL6-1-overexpression plants resulted in an increase in MdTST1/2 expression and sugar concentration. Further studies established that MdSnRK2.3, whose expression could be regulated by expressing MdERDL6-1, could interact with and phosphorylate MdAREB1.1/1.2, thereby promoting the MdAREB1.1/1.2-mediated transcriptional activation of MdTST1/2. Finally, the orthologous SlAREB1.2 and SlSnRK2.3 exhibited similar functions in tomato fruit as in their apple counterparts. Together, our findings provide insights into the regulatory mechanism of tonoplast sugar transport exerted by SnRK2.3-AREB1-TST1/2 for fruit sugar accumulation.
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