ArticleEndocrine2023
A machine learning-based sonomics for prediction of thyroid nodule malignancies.
Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- EnhancingQuantitative imaging in medicine and surgery · 2026Article
- AI-assisted radiomics for classification of benign and non-benign right heart masses in 2D-echocardiography.Journal of translational medicine · 2026Article
- Preliminary machine-learning model with clinical, US, and CEUS features for the diagnosis of thyroid follicular-patterned lesions.BMC medical imaging · 2026Article
- ELTIRADS framework for thyroid nodule classification integrating elastography, TIRADS, and radiomics with interpretable machine learning.Scientific reports · 2025Article
- Navigating the complexity of current interventional radiological approaches for distant metastases in thyroid cancer.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to use ultrasound derived features as biomarkers to assess the malignancy of thyroid nodules in patients who were candidates for FNA according to the ACR TI-RADS guidelines.
methodsTwo hundred and ten patients who met the selection criteria were enrolled in the study and subjected to ultrasound-guided FNA of thyroid nodules. Different radiomics features were extracted from sonographic images, including intensity, shape, and texture feature sets. Least Absolute Shrinkage and Selection Operator (LASSO), Minimum Redundancy Maximum Relevance (MRMR), and Random Forests/Extreme Gradient Boosting Machine (XGBoost) algorithms were used for feature selection and classification of the univariate and multivariate modeling, respectively. Evaluation of models performed using accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC).
resultsIn the univariate analysis, Gray Level Run Length Matrix - Run-Length Non-Uniformity (GLRLM-RLNU) and gray-level zone length matrix - Run-Length Non-Uniformity (GLZLM-GLNU) (both with an AUC of 0.67) were top-performing for predicting nodules malignancy. In the multivariate analysis of the training dataset, the AUC of all combinations of feature selection algorithms and classifiers was 0.99, and the highest sensitivity was for XGBoost classifier and MRMR feature selection algorithms (0.99). Finally, the test dataset was used to evaluate our model in which XGBoost classifier with MRMR and LASSO feature selection algorithms had the highest performance (AUC = 0.95).
conclusionsUltrasound-extracted features can be used as non-invasive biomarkers for thyroid nodules' malignancy prediction.
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Registered trials
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