ArticleNature microbiology2023
A genetic switch controls Pseudomonas aeruginosa surface colonization.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Biofilm-mediated antibiotic tolerance in bacterial pathogens: Integrated molecular networks and novel therapeutic avenues.Virulence · 2026Review
- MAX3 deficiency recruits protective Pseudomonas via modulating the SL-ABA-flavonoid axis to suppress soil-borne pathogen infection.Nature communications · 2026Article
- Two unrelated Pseudomonas aeruginosa phages require the exopolysaccharide Psl for infection.NPJ biofilms and microbiomes · 2025Article
- A biofilm-tropiceLife · 2025Article
- Genetic analysis of flagellar-mediated surface sensing byJournal of bacteriology · 2025Article
- Advanced biomaterials for targeting mature biofilms in periodontitis therapy.Bioactive materials · 2025Review
- Analysis of gene expression within individual cells reveals spatiotemporal patterns underlying Vibrio cholerae biofilm development.PLoS biology · 2025Article
- Colony pattern multistability emerges from a bistable switch.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hyphal growth determines spatial organization and coexistence in a pathogenic polymicrobial community in a spatially structured environment.The ISME journal · 2025Article
- Article
- Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infection.Nature microbiology · 2024Article
- Toxin-mediated depletion of NAD and NADP drives persister formation in a human pathogen.The EMBO journal · 2024Article
- Stress triggers gut dysbiosis via CRH-CRHR1-mitochondria pathway.NPJ biofilms and microbiomes · 2024Article
- Mechanisms of microbial co-aggregation in mixed anaerobic cultures.Applied microbiology and biotechnology · 2024Review
- Upscaling and Risk Evaluation of the Synthesis of the 3,5-Diamino-1H-Pyrazole, Disperazol.International journal of molecular sciences · 2024Article
- High efficacy treatment of murineAntimicrobial agents and chemotherapy · 2024Article
- A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution.Nature communications · 2024Article
- Complete genome sequence ofMicrobiology resource announcements · 2024Article
- Tracking of Bacteriophage Predation onSensors (Basel, Switzerland) · 2024Article
- Review
Corrections and comments
- Commented on by
Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient colonization of mucosal surfaces is essential for opportunistic pathogens like Pseudomonas aeruginosa, but how bacteria collectively and individually adapt to optimize adherence, virulence and dispersal is largely unclear. Here we identified a stochastic genetic switch, hecR-hecE, which is expressed bimodally and generates functionally distinct bacterial subpopulations to balance P. aeruginosa growth and dispersal on surfaces. HecE inhibits the phosphodiesterase BifA and stimulates the diguanylate cyclase WspR to increase c-di-GMP second messenger levels and promote surface colonization in a subpopulation of cells; low-level HecE-expressing cells disperse. The fraction of HecE
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.