ArticleNature genetics2023
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
Open access · greenAbstract read
In one paragraph
Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
22.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pooled it
- Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review.Molecular nutrition & food research · 2025Pooled it
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- Genetic evidence supports a cortical neuroprotective role of GLP-1 receptor activation in Alzheimer's disease: A drug-target Mendelian randomization study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of Different Patterns of Insulin Resistance With Miscarriage in Population With Miscarriage History: a Multicenter Retrospective Cohort Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Shared genetic and molecular architecture between insulin resistance and cognitive performance.medRxiv : the preprint server for health sciences · 2026Article
- Genetic and molecular signatures highlight diverse pathways linking obesity to type 2 diabetes.Nature communications · 2026Article
- Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways.Diabetologia · 2026Article
- GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus.Genome medicine · 2026Article
- Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities.Cell metabolism · 2026Article
- BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation.Nature communications · 2026Article
- Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin Resistance.medRxiv : the preprint server for health sciences · 2026Article
- Effects of FTO Gene rs9939609 and rs17817449 Polymorphisms on Insulin Resistance in Turkish Children With Obesity.Journal of diabetes · 2026Observational
- Dynamic subcellular proteomics identifies regulators of adipocyte insulin action.Nature communications · 2026Article
- Insulin resistance: mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Combining functional annotation and multi-trait fine-mapping methods improves fine-mapping resolution at glycaemic trait loci.Human molecular genetics · 2026Article
- Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.Nature medicine · 2026Article
- Bridging the variant-to-function gap in type 2 diabetes: advances and challenges.Diabetologia · 2026Review
- Improving polygenic risk prediction performance by integrating electronic health records through phenotype embedding.American journal of human genetics · 2025Article
- Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism.Nature communications · 2025Article
Corrections and comments
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Authors and funding
116 authors at 20 institutions in 11 countries.
Alice WilliamsonMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID 0000-0002-7599-9301
Dougall M NorrisMetabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK.
Xianyong YinDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
K Alaine BroadawayDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Anne H MoxleyDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Swarooparani VadlamudiDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Emma P WilsonDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Anne U JacksonDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9672-2547
Vasudha AhujaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Mette K AndersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8227-1469
Zorayr ArzumanyanDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Lori L BonnycastleCenter for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Stefan R BornsteinDepartment of Internal Medicine III, Metabolic and Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Maxi P BretschneiderDepartment of Internal Medicine III, Metabolic and Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Thomas A BuchananDepartment of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine USC, Los Angeles, CA, USA.ORCID 0000-0001-7892-5132
Yi-Cheng ChangGraduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei City, Taiwan.
Lee-Ming ChuangDepartment of Internal Medicine, Division of Endocrinology and Metabolism, National Taiwan University Hospital, Taipei City, Taiwan.ORCID 0000-0003-0978-2662
Ren-Hua ChungInstitute of Population Health Sciences, National Health Research Institutes, Toufen, Taiwan.ORCID 0000-0002-9835-6333
Tine D ClausenDepartment of Gynecology and Obstetrics, Nordsjaellands Hospital, Hillerød, Denmark.
Peter DammDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2067-5246
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vanessa D de MelloInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0003-2871-3603
Om P DwivediInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0001-8670-7717
Michael R ErdosCenter for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6603-1833
Lilian Fernandes SilvaInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-0225-842X
Timothy M FraylingUniversity of Exeter Medical School University of Exeter, Exeter, UK.ORCID 0000-0001-8362-2603
Christian GiegerGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID 0000-0001-6986-9554
Mark O GoodarziDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-6364-5103
Xiuqing GuoDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5264-5068
Stefan GustafssonDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-5894-0351
Liisa HakasteInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Ulf HammarDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Gad HatemClinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden.
Sandra HerrmannHelmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.
Kurt HøjlundSteno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Katrin HornMedical Faculty Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.ORCID 0000-0002-5307-6936
Willa A HsuehInternal Medicine, Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Yi-Jen HungInstitute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan.
Chii-Min HwuDepartment of Medicine Section of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei City, Taiwan.ORCID 0000-0002-8209-9627
Anna JonssonNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Line L KårhusCenter for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Marcus E KleberInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-0663-7275
Peter KovacsMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.ORCID 0000-0002-0290-5423
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-9199-2871
Marie LauzonDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
I-Te LeeDepartment of Internal Medicine Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung City, Taiwan.
Cecilia M LindgrenBig Data Institute Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Jaana LindströmFinnish Institute for Health and Welfare, Helsinki, Finland.
Allan LinnebergDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-0994-0184
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-0703-0742
Jian'an LuanMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID 0000-0003-3137-6337
Dina Mansour AlyClinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden.
Elisabeth MathiesenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Angela P MoisslInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-0302-2136
Andrew P MorrisCentre for Genetics and Genomics Versus Arthritis Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.ORCID 0000-0002-6805-6014
Narisu NarisuCenter for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8483-1156
Nikolaos PerakakisDepartment of Internal Medicine III, Metabolic and Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Annette PetersGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.ORCID 0000-0001-6645-0985
Rashmi B PrasadInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4400-6741
Roman N RodionovDepartment of Internal Medicine III, University Center for Vascular Medicine, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Kathryn RollPediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Carsten F RundstenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Chloé SarnowskiDepartment of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, Houston, TX, USA.ORCID 0000-0002-6090-7099
Kai SavonenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Markus ScholzMedical Faculty Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.ORCID 0000-0002-4059-1779
Sapna SharmaResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Sara E StinsonNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sufyan SulemanNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jingyi TanDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kent D TaylorDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Dorte VistisenClinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.
Daniel R WitteSteno Diabetes Center Aarhus, Aarhus, Denmark.
Romy WaltherHelmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.
Peitao WuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Anny H XiangResearch and Evaluation, Division of Biostatistics, Kaiser Permanente Southern California, Pasadena, CA, USA.
Björn ZetheliusDepartment of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
Emma AhlqvistClinical Sciences Malmö, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden.ORCID 0000-0002-6513-2384
Richard N BergmanDiabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yii-Der Ida ChenDepartment of Pediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Francis S CollinsCenter for Precision Health Research National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1023-7410
Tove FallDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2071-5866
Jose C FlorezDiabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Andreas FritscheDepartment of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.
Harald GrallertGerman Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
Leif GroopInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0187-3263
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Heikki A KoistinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-7870-070X
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Markku LaaksoInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-3394-7749
Lars LindDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.
Markus LoefflerMedical Faculty Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
James B MeigsDepartment of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.
Leslie J RaffelDepartment of Pediatrics, Genetic and Genomic Medicine, University of California, Irvine, CA, USA.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Peter E H SchwarzHelmholtz Zentrum München Paul Langerhans Institute Dresden (PLID), University Hospital and Faculty of Medicine TU Dresden, Dresden, Germany.ORCID 0000-0001-6317-7880
Michael StumvollMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.ORCID 0000-0001-6225-8240
Johan SundströmDepartment of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-2247-8454
Anke TönjesMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Tiinamaija TuomiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-8306-6202
Jaakko TuomilehtoDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Robert WagnerDepartment of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany.ORCID 0000-0002-6120-0191
Inês BarrosoExeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0001-5800-4520
Mark WalkerFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5526-1070
Michael BoehnkeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6442-7754
Nicholas J WarehamMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID 0000-0003-1422-2993
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA. karen_mohlke@med.unc.edu.ORCID 0000-0001-6721-153X
Eleanor WheelerMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK. eleanor.wheeler@mrc-epid.cam.ac.uk.ORCID 0000-0002-8616-6444
Stephen O'RahillyMetabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk.ORCID 0000-0003-2199-4449
Daniel J FazakerleyMetabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK. djf72@cam.ac.uk.ORCID 0000-0001-8241-2903
Claudia LangenbergMRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK. claudia.langenberg@qmul.ac.uk.ORCID 0000-0002-5017-7344
University of Copenhagen · DKHelmholtz Zentrum München · DEUCLA Medical Center · USUniversity of Eastern Finland · FIUniversity of Helsinki · FIUniversity of Cambridge · GBUppsala University · SEUniversity of North Carolina at Chapel Hill · USLund University · SENational Institutes of Health · USBoston University · USLife University · USUniversity of Michigan · USBroad Institute · USCedars-Sinai Medical Center · USHeidelberg University · DESteno Diabetes Centers · DKUniversity Children's Hospital Tübingen · DEUniversity of Exeter · GBFinnish Institute for Health and Welfare · FI
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MGenetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8MTargeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MGenetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MThe Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)T32HL129982 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery, KAREN L. MOHLKE · 2016 to 2026
$3.8MPredoctoral Training Program in Bioinformatics and Computational BiologyT32GM135123 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Isaiah Love, William Valdar · 2021 to 2026
$1.7MMentoring Investigators on the Clinical Translation of Genetic Discoveries in Type 2 DiabetesK24DK110550 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2016 to 2020
$812kExploring Common Biological Pathways Underlying Insulin Resistance and Alzheimer Disease using Genetic and Omic ToolsR00AG066849 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SARNOWSKI, CHLOÉ · 2022 to 2024
$726kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–Intramural NIH HHS ZIA HG000024Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/5Medical Research Council MC UU 12015/1Medical Research Council MC_UU_12015/1Medical Research Council MR/S007091/1NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL105756NHLBI NIH HHS T32 HL129982NIA NIH HHS R00 AG066849NIDDK NIH HHS K24 DK110550NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIGMS NIH HHS T32 GM135123
Abstract
Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10
Indexed as
Diabetes Mellitus, Type 2Insulin ResistanceBlood GlucoseGenome-Wide Association StudyGlucoseHumansInsulinBlood GlucoseGlucoseInsulin
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