ArticleTranslational psychiatry2023
Dissecting the causal association between social or physical inactivity and depression: a bidirectional two-sample Mendelian Randomization study.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Domain-specific physical activity and mental health: an updated systematic review and multilevel meta-analysis in a combined sample of 3.3 million people.British journal of sports medicine · 2026Pooled it
- Cognition, Depression, Pain, and Exercise Motives as Predictors of Longitudinal Profiles of Physical Activity During a Seven-Year Follow-Up Among Older Adults.Scandinavian journal of medicine & science in sports · 2024Trial
- The Influence of Health, Marriage and Cohabitation on Physical Inactivity: Evidence from SHARE for 12 European Countries.Research square · 2026Article
- Gene-Physical Activity Interplay in Depression: Candidate-Gene Interactions, Polygenic Susceptibility, Lifestyle Context, and Mendelian Randomization Evidence-Systematic Review.Journal of clinical medicine · 2026Review
- Shared genetic architecture between ADHD and intelligence varies across ADHD subtypes.BMC medicine · 2026Article
- Article
- Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization.European archives of psychiatry and clinical neuroscience · 2025Article
- Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.Nature communications · 2025Article
- Investigating the visceral adiposity-major depressive disorder link: a cross-sectional NHANES 2011-2014 analysis and Mendelian randomization study.Eating and weight disorders : EWD · 2025Article
- Physical activity, health, and life satisfaction: Four panel studies demonstrate reciprocal effects.Applied psychology. Health and well-being · 2025Article
- Reduced Cortical Surface Area in the Frontal Operculum as a Causal Risk Predictor for Chronic Pain.Pain research & management · 2025Article
- Joint Trajectories of Physical Activity and Depressive Symptoms in Postmenopausal Women in China: A Group-Based Dual Trajectory Analysis of the Five-Year Longitudinal Study.Journal of multidisciplinary healthcare · 2025Article
- Improvements in physical activity and depression symptoms: an observational study of users of a multi-modal digital mental health platform.Frontiers in digital health · 2025Article
- Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.The journal of headache and pain · 2024Article
- Article
- Causality between Sarcopenia and Depression: A Bidirectional Mendelian Randomization Study.Actas espanolas de psiquiatria · 2024Article
- Bidirectional Association between Sarcopenia and Depressive Symptoms among Chinese Middle- and Older-Aged Adults: Longitudinal Observational Study.Brain sciences · 2024Article
- Assessment of Causality Between Diet-Derived Antioxidants and Primary Open-Angle Glaucoma: A Mendelian Randomization Study.Translational vision science & technology · 2024Article
- Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies.Frontiers in neuroscience · 2024Review
- The Role of Polyunsaturated Fatty Acids in Osteoarthritis: Insights from a Mendelian Randomization Study.Nutrients · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of research suggests that social or physical activity can affect the risk of Major depressive disorder (MDD). However, the bidirectional relationship between them remains to be clarified further, especially between inactivity and MDD. Here, we performed a two-sample Mendelian Randomization analysis using genetic variants associated with social/physical activities and MDD, and assessed the mediating effect of obesity-related measures and brain imaging phenotypes. The dataset on MDD, social activities, and physical activities included 500,199; 461,369; 460,376 individuals, respectively. Information regarding body mass index (BMI), body fat percentage (BFP), IDPs for 454,633; 461,460; 8,428 participants, respectively. We identified bidirectional causal relationships between sport clubs or gyms, strenuous sports, heavy do-it-youself, other exercises and MDD. We also observed that leisure/social inactivity (odds ratio [OR] = 1.64; P = 5.14 × 10
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.