Evidence map›Paper›PMID 37291068›Full record

ArticleThe Kobe journal of medical sciences2023

Safety of Low-Dose Oral Food Challenges for Hen's Eggs, Cow's Milk, and Wheat: Report from a General Hospital without Allergy Specialists in Japan.

Keita Nakanishi, Ikuo Okafuji, Takashi Kihara, Yukino Kawanami, Ayaka Shimizu, Shinpei Kotani, Yoshiaki Kamoi, Takahiro Okutani

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Kobe journal of medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 69% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Keita NakanishiDepartment of Pediatrics, Saiseikai Hyogoken Hospital, Kobe, Japan.
Ikuo OkafujiDepartment of Pediatrics, Kobe City Medical Center General Hospital, Kobe, Japan.
Takashi KiharaDepartment of Pediatrics, Kobe City Medical Center General Hospital, Kobe, Japan.
Yukino KawanamiDepartment of Pediatrics, Saiseikai Hyogoken Hospital, Kobe, Japan.
Ayaka ShimizuDepartment of Pediatrics, Saiseikai Hyogoken Hospital, Kobe, Japan.
Shinpei KotaniDepartment of Pediatrics, Saiseikai Hyogoken Hospital, Kobe, Japan.
Yoshiaki KamoiDepartment of Pediatrics, Saiseikai Hyogoken Hospital, Kobe, Japan.
Takahiro OkutaniDepartment of Pediatrics, Saiseikai Hyogoken Hospital, Kobe, Japan.
Kobe Kaisei Hospital · JPKobe City Medical Center General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An oral food challenge (OFC) is useful for managing food allergies. However, because OFCs have the risk of severe allergic reactions, including anaphylaxis, conducting OFCs under this situation without allergy specialists is difficult. To investigate the safety of a low-dose OFC for eggs, milk, and wheat in a general hospital without allergy specialists. We retrospectively analyzed the medical records of children who were hospitalized in a general hospital without allergy specialists for a low-dose OFC of egg, milk, or wheat between April 2018 and March 2021. The records of 108 patients were evaluated. The median age was 15.8 months (range: 7.5-69.3 months). Challenged foods were eggs (n = 81), milk (n = 23), and wheat (n = 4). Fifty-three (49.0%) patients showed positive allergic reactions. Thirty-five (66.0%) patients showed grade 1 (mild), 18 (34.0%) showed grade 2 (moderate), and none showed grade 3 (severe) reactions. The interventions comprised antihistamines (n = 18), prednisolone (n = 3), inhaled Β2-agonist (n = 2). No patients required adrenaline and no deaths occurred. Low-dose OFCs may be safe in a general hospital without allergy specialists. Conducting a low-dose OFC may be essential in food allergy practice.

Indexed as

AllergensFood HypersensitivityAnimalsCattleChickensChildChild, PreschoolEggsHospitals, GeneralHumansInfantJapanMilkRetrospective StudiesTriticumAllergensAnaphylaxisFood allergyFood hypersensitivityGuidelinesSafety

Identifiers

PMID37291068
PMCPMC10306261
OpenAlexW4379966407

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.