Evidence map›Paper›PMID 37290938›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy.

William F Tobin, Matthew C Weston

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

William F TobinDepartment of Neurological Sciences, University of Vermont, Burlington, VT 05405.
Matthew C WestonDepartment of Neurological Sciences, University of Vermont, Burlington, VT 05405 mcweston7c@vtc.vt.edu.ORCID 0000-0001-5558-7070
University of Vermont · US

Funding

Synaptic changes and hypersynchronous network activity in mTORopathiesR01NS110945 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WESTON, MATTHEW C · 2019 to 2023
$1.7M
Cell Type-Specific Roles of the Na-Activated K Current in KCNT1-Related EpilepsyR01NS130042 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Matthew C Weston · 2023 to 2026
$1.6M
NINDS NIH HHS R01 NS110945NINDS NIH HHS R01 NS130042
6 · The paper itself

Abstract

The epileptic brain is distinguished by spontaneous seizures and interictal epileptiform discharges (IEDs). Basic patterns of mesoscale brain activity outside of seizures and IEDs are also frequently disrupted in the epileptic brain and likely influence disease symptoms, but are poorly understood. We aimed to quantify how interictal brain activity differs from that in healthy individuals, and identify what features of interictal activity influence seizure occurrence in a genetic mouse model of childhood epilepsy. Neural activity across the majority of the dorsal cortex was monitored with widefield Ca

Indexed as

EpilepsySeizuresAnimalsBrainBrain MappingElectroencephalographyFemaleHumansMaleMiceCa2+ imaginggenetic epilepsy KCNT1mesoscaleseizures

Identifiers

PMID37290938
PMCPMC10324994
OpenAlexW4379928807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.