ArticleThe British journal of ophthalmology2024
Myopic maculopathy among Chinese children with high myopia and its association with choroidal and retinal changes: the SCALE-HM study.
Article in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03666052 (Shanghai Child and Adolescent Large-scale Eye Study -High Myopia Registration), which is not on this map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Shanghai Child and Adolescent Large-scale Eye Study -High Myopia Registration
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- The Effect of Three-Dimensional Ocular Shape on Longitudinal Biometric Changes: A Six-Year Follow-Up Study.Translational vision science & technology · 2026Article
- Longitudinal OCTA Evaluation of Optic Nerve Head Microvasculature in Non-Highly Myopic Eyes With Peripapillary Fundus Tessellation Over Six Years.Investigative ophthalmology & visual science · 2026Article
- Epidemiology of Myopia Occurrence, Development, and Correction in Primary School Students in China: A Retrospective Cohort Study.Health science reports · 2025Article
- Comprehensive analysis of posterior segment characteristics in high myopic Turkish patients.BMC ophthalmology · 2025Article
- An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning.Translational vision science & technology · 2025Article
- Diagnostic challenges in high myopia: identification of sight-threatening complications and the role of artificial intelligence.Frontiers in ophthalmology · 2025Review
- Choroidal vascular changes in early-stage myopic maculopathy from deep learning choroidal analysis: a hospital-based SS-OCT study.Eye and vision (London, England) · 2024Article
- Long-term outcomes of anti-vascular endothelial growth factor therapy with and without posterior scleral reinforcement on myopic maculopathy in myopic choroidal neovascularization eyes.BMC ophthalmology · 2024Article
- Peripheral and posterior pole retinal changes in highly myopic Chinese children and adolescents : Retinal changes in Chinese children and adolescents.BMC ophthalmology · 2024Article
- Screening of genes interacting with high myopia and neuropsychiatric disorders.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate myopic maculopathy in Chinese children with high myopia and its association with choroidal and retinal changes.
methodsThis cross-sectional study included Chinese children aged 4-18 years with high myopia. Myopic maculopathy was classified by fundus photography and retinal thickness (RT) and choroidal thickness (ChT) in the posterior pole were measured by swept-source optical coherence tomography. A receiver operation curve was used to determine the efficacy of fundus factors in classifying myopic maculopathy.
resultsIn total, 579 children aged 12.8±3.2 years with a mean spherical equivalent of -8.44±2.20 D were included. The proportions of tessellated fundus and diffuse chorioretinal atrophy were 43.52% (N=252) and 8.64% (N=50), respectively. Tessellated fundus was associated with a thinner macular ChT (OR=0.968, 95% CI: 0.961 to 0.975, p<0.001) and RT (OR=0.977, 95% CI: 0.959 to 0.996, p=0.016), longer axial length (OR=1.545, 95% CI: 1.198 to 1.991, p=0.001) and older age (OR=1.134, 95% CI: 1.047 to 1.228, p=0.002) and less associated with male children (OR=0.564, 95% CI: 0.348 to 0.914, p=0.020). Only a thinner macular ChT (OR=0.942, 95% CI: 0.926 to 0.959, p<0.001) was independently associated with diffuse chorioretinal atrophy. When using nasal macular ChT for classifying myopic maculopathy, the optimal cut-off value was 129.00 µm (area under the curve (AUC)=0.801) and 83.85 µm (AUC=0.910) for tessellated fundus and diffuse chorioretinal atrophy, respectively.
conclusionA large proportion of highly myopic Chinese children suffer from myopic maculopathy. Nasal macular ChT may serve as a useful index for classifying and assessing paediatric myopic maculopathy. TRIAL REGISTRATION NUMBER: NCT03666052.
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