Evidence map›Paper›PMID 37290817›Full record

ArticleAJNR. American journal of neuroradiology2023

Sex-Specific Patterns of Cerebral Atrophy and Enlarged Perivascular Spaces in Patients with Cerebral Amyloid Angiopathy and Dementia.

J Pinho, F C Almeida, J M Araújo, Á Machado, A S Costa, F Silva, A Francisco, M Quintas-Neves, C Ferreira, J P Soares-Fernandes and 1 more

Open access · hybridAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Non-hemorrhagic imaging markers of cerebral amyloid angiopathy in memory clinic patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

J PinhoFrom the Department of Neurology (J.P., A.S.C.), University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0002-3977-7146
F C AlmeidaLife and Health Sciences Research Institute (F.C.A., M.Q.-N., T.G.O.), School of Medicine.
J M AraújoDepartments of Neurology (J.M.A., Á.M., C.F.).
Á MachadoDepartments of Neurology (J.M.A., Á.M., C.F.).
A S CostaFrom the Department of Neurology (J.P., A.S.C.), University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0002-1999-6616
F SilvaAlgoritmi Center (F.S., A.F.), University of Minho, Braga, Portugal.
A FranciscoAlgoritmi Center (F.S., A.F.), University of Minho, Braga, Portugal.
M Quintas-NevesLife and Health Sciences Research Institute (F.C.A., M.Q.-N., T.G.O.), School of Medicine.ORCID 0000-0002-8183-5717
C FerreiraDepartments of Neurology (J.M.A., Á.M., C.F.).
J P Soares-FernandesNeuroradiology (M.Q.-N., J.P.S.-F., T.G.O.), Hospital de Braga, Braga, Portugal.
T G OliveiraLife and Health Sciences Research Institute (F.C.A., M.Q.-N., T.G.O.), School of Medicine tiago@med.uminho.pt.ORCID 0000-0003-0509-0562
Hospital Braga · PTMACOM (United States) · USUniversity of Minho · PTForschungszentrum Jülich · DERWTH Aachen University · DEUnited Nations University · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeCerebral amyloid angiopathy is characterized by amyloid β deposition in leptomeningeal and superficial cortical vessels. Cognitive impairment is common and may occur independent of concomitant Alzheimer disease neuropathology. It is still unknown which neuroimaging findings are associated with dementia in cerebral amyloid angiopathy and whether they are modulated by sex. This study compared MR imaging markers in patients with cerebral amyloid angiopathy with dementia or mild cognitive impairment or who are cognitively unimpaired and explored sex-specific differences. MATERIALS AND

methodsWe studied 58 patients with cerebral amyloid angiopathy selected from the cerebrovascular and memory outpatient clinics. Clinical characteristics were collected from clinical records. Cerebral amyloid angiopathy was diagnosed on MR imaging on the basis of the Boston criteria. Visual rating scores for atrophy and other imaging features were independently assessed by 2 senior neuroradiologists.

resultsMedial temporal lobe atrophy was higher for those with cerebral amyloid angiopathy with dementia versus those cognitively unimpaired (

conclusionsMedial temporal lobe atrophy was more prominent in men with dementia, whereas women showed a higher number of enlarged perivascular spaces in the centrum semiovale. Overall, this finding suggests differential pathophysiologic mechanisms with sex-specific neuroimaging patterns in cerebral amyloid angiopathy.

Indexed as

Alzheimer DiseaseCerebral Amyloid AngiopathyAmyloid beta-PeptidesAtrophyFemaleHumansMagnetic Resonance ImagingMaleAmyloid beta-Peptides

Identifiers

PMID37290817
PMCPMC10337609
OpenAlexW4379792476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.