Evidence map›Paper›PMID 37290124›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.

Elizabeth A Barnes, Carsten Knutsen, Alida Kindt, Xibing Che, Lihua Ying, Eloa Adams, Erika Gonzalez, Prajakta Oak, Anne Hilgendorff, Cristina M Alvira and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Got Oxygen? Studies on Mesenchymal Cell Hypoxia Inducible Factor-1α in Lung Development.American journal of respiratory cell and molecular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Elizabeth A BarnesDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.ORCID 0000-0002-9857-8657
Carsten KnutsenDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.
Alida KindtMetabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands; and.
Xibing CheDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.
Lihua YingDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.
Eloa AdamsDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.
Erika GonzalezComprehensive Pneumology Center, Ludwig Maximilian University of Munich, Munich, Germany.
Prajakta OakComprehensive Pneumology Center, Ludwig Maximilian University of Munich, Munich, Germany.
Anne HilgendorffComprehensive Pneumology Center, Ludwig Maximilian University of Munich, Munich, Germany.
Cristina M AlviraDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.ORCID 0000-0002-6921-0001
David N CornfieldDivision of Pulmonary, Asthma, and Sleep Medicine, Center for Excellence in Pulmonary Biology, and.ORCID 0000-0002-1684-2056
Center for Excellence in Education · USLudwig-Maximilians-Universität München · DELeiden University · NL

Funding

Novel pathways regulating calcium mediated contractility in the pregnant uterusR01HD092316 · NICHD · STANFORD UNIVERSITY · PI ALVIRA, CRISTINA MARIA, CORNFIELD, DAVID N. · 2018 to 2022
$2.7M
Pericytes and postnatal alveolarization: Role of hypoxia inducible factorsR01HL160018 · NHLBI · STANFORD UNIVERSITY · PI ALVIRA, CRISTINA MARIA, CORNFIELD, DAVID N. · 2022 to 2025
$2.6M
DEVELOPMENTAL REGULATION OF OXYGEN SENSING IN THE LUNGR01HL060784 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CORNFIELD, DAVID N. · 1999 to 2009
$2.2M
NHLBI NIH HHS R01 HL060784NHLBI NIH HHS R01 HL160018NICHD NIH HHS R01 HD092316
6 · The paper itself

Abstract

Worldwide, the incidence of both preterm births and chronic lung disease of infancy, or bronchopulmonary dysplasia, remains high. Infants with bronchopulmonary dysplasia have larger and fewer alveoli, a lung pathology that can persist into adulthood. Although recent data point to a role for hypoxia-inducible factor-1α (HIF-1α) in mediating pulmonary angiogenesis and alveolarization, the cell-specific role of HIF-1α remains incompletely understood. Thus, we hypothesized that HIF-1α, in a distinct subset of mesenchymal cells, mediates postnatal alveolarization. To test the hypothesis, we generated mice with a cell-specific deletion of HIF-1α by crossing SM22α promoter-driven Cre mice with HIF-1α

Indexed as

Angiopoietin-2Bronchopulmonary DysplasiaHypoxia-Inducible Factor 1, alpha SubunitAnimalsHumansInfant, NewbornInfant, PrematureLungMiceMicrofilament ProteinsMuscle ProteinsAngiopoietin-2HIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMicrofilament ProteinsMuscle ProteinsTagln protein, mousetransgelinangiopoietin-2bronchopulmonary dysplasialung developmentoxygen sensing

Identifiers

PMID37290124
PMCPMC10557922
OpenAlexW4379794671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.