Evidence map›Paper›PMID 37289955›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023

Worsening of lung perfusion to tissue density distributions during early acute lung injury.

Gabriel C Motta-Ribeiro, Tilo Winkler, Eduardo L V Costa, Nicolas de Prost, Mauro R Tucci, Marcos F Vidal Melo

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Gabriel C Motta-RibeiroBiomedical Engineering Program, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0001-5982-8863
Tilo WinklerDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-7276-5550
Eduardo L V CostaDivisão de Pneumologia, Faculdade de Medicina, Instituto do Coração (Incor), Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0002-6941-3626
Nicolas de ProstHôpitaux Universitaires Henri Mondor and Université Paris Est Créteil and INSERM - Unité U955, Créteil, France.
Mauro R TucciDivisão de Pneumologia, Faculdade de Medicina, Instituto do Coração (Incor), Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.
Marcos F Vidal MeloDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, New York, United States.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRColumbia University Irving Medical Center · USHarvard University · USInserm · FRUniversidade Federal do Rio de Janeiro · BR

Funding

Regional Tidal Lung Strain and Neutrophilic Inflammation in Early Lung InjuryR01HL121228 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI VIDAL MELO, MARCOS F · 2014 to 2023
$6.2M
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 6344/15-1HHS | National Institutes of Health (NIH) R01-HL121228NHLBI NIH HHS R01 HL121228
6 · The paper itself

Abstract

Lung perfusion magnitude and distribution are essential for oxygenation and, potentially, lung inflammation and protection during acute respiratory distress syndrome (ARDS). Yet, perfusion patterns and their relationship to inflammation are unknown pre-ARDS. We aimed to assess perfusion/density ratios and spatial perfusion-density distributions and associate these to lung inflammation, during early lung injury in large animals at different physiological conditions caused by different systemic inflammation and positive end-expiratory pressure (PEEP) levels. Sheep were protectively ventilated (16-24 h) and imaged for lung density, pulmonary capillary perfusion (

Indexed as

Acute Lung InjuryEndotoxemiaPneumoniaPulmonary AtelectasisRespiratory Distress SyndromeAnimalsFluorodeoxyglucose F18InflammationLungNitrogenPerfusionSheepFluorodeoxyglucose F18Nitrogenmechanical ventilationperfusion imagingPET imagingventilator-induced lung injury

Identifiers

PMID37289955
PMCPMC10393328
OpenAlexW4379792882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.