ArticleScience (New York, N.Y.)2023
Taurine deficiency as a driver of aging.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06613542 (Effect Of Daily Taurine Supplementation For 6 Months On Biological Age and Metabolic Biomarkers As Well As Physical Fitness In 55-75-year-old Women And Men), which is not on this map. Cited by 254 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 2 pooled it
85.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect Of Daily Taurine Supplementation For 6 Months On Biological Age and Metabolic Biomarkers As Well As Physical Fitness In 55-75-year-old Women And Men: A Randomized Controlled Intervention Study
Who cites it
254 citing papers in PubMed, 2 syntheses or guidelines pooled it, 374 citations in OpenAlex.
- Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- The impact of cysteine on lifespan in three model organisms: A systematic review and meta-analysis.Aging cell · 2025Pooled it
- Trial
- A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial.Frontiers in nutrition · 2026Trial
- Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study.BMC oral health · 2025Trial
- In Vivo Measurement of Taurine With Optimized Double-Quantum Filtering Magnetic Resonance Spectroscopy.Magnetic resonance in medicine · 2026Article
- Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.Nature aging · 2026Article
- Inhibiting Glutaminase Reverses Senescence-Associated Mitochondrial Dysfunction and Skeletal Muscle Decline.Aging cell · 2026Article
- Association of three different dietary patterns with the metabolomic profiles of children: the BiomarKid project.European journal of nutrition · 2026Article
- Gut Microbiota and Brain Aging: Identifying Keystone Biomarkers for Cognitive Health.Biomedicines · 2026Review
- Autophagy modulation in cancer.Nature reviews. Drug discovery · 2026Review
- Geroprotective Effects of Drugs Modulating Metabolic Pathways: Perspectives of Pharmacology in Anti-Aging Therapy.International journal of molecular sciences · 2026Review
- Effects of a Multi-Ingredient MCT-Leucine-Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial.Life (Basel, Switzerland) · 2026Article
- Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.Cell metabolism · 2026Article
- Loss of TET2 sulfhydration results in destabilization of TET2 and down-regulation of the immune response in melanoma.Acta pharmaceutica Sinica. B · 2026Article
- Bioactive Collagen Peptides in Veterinary and Biomedical Science-Part II: The Gut-Collagen Peptide Axis, Bile Acid Signaling, and Translational Therapeutic Applications.Veterinary sciences · 2026Review
- Separation of Taurine and Sodium Sulfate from Simulated Mother Liquor by Electrodialysis and Process Optimization.Membranes · 2026Article
- Hypercholesterolemia induced by hypothyroidism is ameliorated by taurine supplementation through the hepatic AMPK/ACC pathway.Archives of endocrinology and metabolism · 2026Article
- Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults.Cell reports. Medicine · 2026Observational
- Gut Metabolism Links Precision Nutrition, Exercise, and Healthspan in Drosophila melanogaster.Aging cell · 2026Article
194 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
56 authors at 20 institutions in 10 countries.
Parminder Singh *Metabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0002-2851-6805
Kishore Gollapalli *Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0002-9546-2472
Stefano Mangiola *The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0001-7474-836X
Daniela Schranner *Exercise Biology Group, Technical University of Munich, Munich, Germany.ORCID 0000-0003-2316-318X
Mohd Aslam Yusuf *Department of Bioengineering, Integral University, Lucknow, India.ORCID 0000-0003-2779-9919
Manish Chamoli *Buck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0003-0339-7894
Sting L ShiVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.ORCID 0000-0003-0264-7011
Bruno Lopes BastosInstitute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.ORCID 0000-0002-0517-9455
Tripti NairMolecular Aging Laboratory, National Institute of Immunology, New Delhi, India.ORCID 0000-0002-5380-4622
Annett RiermeierExercise Biology Group, Technical University of Munich, Munich, Germany.
Elena M VayndorfDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9416-3350
Judy Z WuDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Aishwarya NilakheMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0002-6669-5330
Christina Q NguyenDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Michael MuirDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-5596-3443
Michael G KiflezghiDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3318-3686
Anna FoulgerBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0003-4135-9741
Alex JunkerDepartment of Neurology, Columbia University, New York, NY, USA.ORCID 0000-0003-1746-7160
Jack DevineDepartment of Neurology, Columbia University, New York, NY, USA.
Kunal SharanMouse Genetics Project, Wellcome Sanger Institute, Cambridge, UK.ORCID 0000-0003-2139-2544
Shankar J ChintaBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0001-6386-6790
Swati RajputDivision of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.ORCID 0000-0003-2079-965X
Anand RaneBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0001-5886-5291
Philipp BaumertExercise Biology Group, Technical University of Munich, Munich, Germany.ORCID 0000-0002-5463-1954
Martin SchönfelderExercise Biology Group, Technical University of Munich, Munich, Germany.ORCID 0000-0002-3003-3378
Francescopaolo IavaroneTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0002-8855-1848
Giorgia di LorenzoTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0001-8659-5268
Swati KumariMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0003-0607-8098
Alka GuptaMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0001-8126-3475
Rajesh SarkarMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0001-7779-031X
Costerwell KhyriemHarry Perkins Institute of Medical Research, Perth, WA, Australia.ORCID 0000-0003-2078-2532
Amanpreet S ChawlaImmunobiology Laboratory, National Institute of Immunology, New Delhi, India.
Ankur SharmaHarry Perkins Institute of Medical Research, Perth, WA, Australia.ORCID 0000-0002-6862-136X
Nazan SarperPediatrics and Pediatric Hematology, Kocaeli University Hospital, Kocaeli, Turkey.ORCID 0000-0003-1599-774X
Naibedya ChattopadhyayDivision of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India.ORCID 0000-0003-2473-0246
Bichitra K BiswalMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0002-5927-3244
Carmine SettembreTelethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.ORCID 0000-0002-5829-8589
Perumal NagarajanPrimate Research Facility, National Institute of Immunology, New Delhi, India.ORCID 0000-0003-4557-4633
Kimara L TargoffDivision of Cardiology, Department of Pediatrics, Columbia University, New York, NY, USA.ORCID 0000-0002-6066-6002
Martin PicardDepartment of Neurology, Columbia University, New York, NY, USA.ORCID 0000-0003-2835-0478
Sarika GuptaMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0002-3054-0337
Vidya VelagapudiInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Anthony T PapenfussThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0002-1102-8506
Alaattin KayaDepartment of Biology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0002-6132-5197
Miguel Godinho FerreiraInstitute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.ORCID 0000-0002-8363-7183
Brian K KennedyHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-5754-1874
Julie K AndersenBuck Institute for Research on Aging, Novato, CA, USA.
Gordon J LithgowBuck Institute for Research on Aging, Novato, CA, USA.ORCID 0000-0002-8953-3043
Abdullah Mahmood AliDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4007-6769
Arnab MukhopadhyayMolecular Aging Laboratory, National Institute of Immunology, New Delhi, India.ORCID 0000-0002-5266-7849
Aarno PalotieInstitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Gabi KastenmüllerInstitute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-2368-7322
Matt KaeberleinDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1311-3421
Henning WackerhageExercise Biology Group, Technical University of Munich, Munich, Germany.
Bhupinder PalThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0002-3684-4331
Vijay K YadavMetabolic Research Laboratories, National Institute of Immunology, New Delhi, India.ORCID 0000-0003-2345-2846
National Institute of Immunology · INBuck Institute for Research on Aging · USUniversity of Washington · USColumbia University · USTechnical University of Munich · DEThe University of Melbourne · AUCentral Drug Research Institute · INColumbia University Irving Medical Center · USCurtin University · AUHelmholtz Zentrum München · DEInstitut de Recherche sur le Cancer et le Vieillissement de Nice · FRTelethon Institute Of Genetics And Medicine · ITWellcome Sanger Institute · GBBroad Institute · USFederico II University Hospital · ITIntegral University · INKocaeli Üniversitesi · TRMRC Protein Phosphorylation and Ubiquitylation Unit · GBNational University of Singapore · SGUniversity of Helsinki · FI
Funding
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Maitreya J Dunham · 1995 to 2026
$27.1MBiological Mechanisms of Healthy Aging Training GrantT32AG066574 · NIA · UNIVERSITY OF WASHINGTON · PI David J. Marcinek, Jessica E Young · 2020 to 2026
$5.3MMechanisms of second heart field development regulated by Nkx genesR01HL131438 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TARGOFF, KIMARA L · 2017 to 2021
$2.1MMechanisms of outflow tract morphogenesis regulated by extracellular matrixR01HL170188 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIMARA L TARGOFF · 2023 to 2026
$2.1MMechanisms of myocardial regeneration mediated by Nkx2.5 in zebrafishR01HL162989 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIMARA L TARGOFF · 2023 to 2026
$2.0MRegulation of adrenal development and function by the mother's skeletonR01HD107574 · NICHD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YADAV, VIJAY K · 2021 to 2025
$1.7MNHLBI NIH HHS R01 HL131438NHLBI NIH HHS R01 HL162989NHLBI NIH HHS R01 HL170188NIA NIH HHS P30 AG013280NIA NIH HHS T32 AG066574NICHD NIH HHS R01 HD107574Wellcome Trust
Abstract
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
Indexed as
AgingTaurineAnimalsCellular SenescenceDietary SupplementsDNA DamageHaplorhiniHumansLongevityMiceTelomeraseTaurineTelomerase
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06613542ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.