ArticlePloS one2023
Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The myth of digital biomarkers in Alzheimer's disease: how to make them a reality.Current opinion in psychiatry · 2026Review
- Research on Threshold Optimization and Variability-Based Digital Biomarker Approaches Through MMSE-Lifelog Multimodal Integrated Analysis from a Clinical Screening Perspective.Healthcare (Basel, Switzerland) · 2026Article
- Enhancing Early Diagnosis: Multimodal AI Approaches for Neurodegenerative Diseases.Journal of biotechnology and biomedicine · 2026Article
- Wearable Sensor Technologies and Gait Analysis for Early Detection of Dementia: Trends and Future Directions.Sensors (Basel, Switzerland) · 2025Review
- Hand Motion Control Ability Between Young and Older Adults: Comparative Study.JMIR formative research · 2025Article
- Developing digital health technologies for frontotemporal degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- From screens to cognition: A scoping review of the impact of screen time on cognitive function in midlife and older adults.Digital healthReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundOutcome measures available for use in Alzheimer's disease (AD) clinical trials are limited in ability to detect gradual changes. Measures of everyday function and cognition assessed unobtrusively at home using embedded sensing and computing generated "digital biomarkers" (DBs) have been shown to be ecologically valid and to improve efficiency of clinical trials. However, DBs have not been assessed for their relationship to AD neuropathology.
objectivesThe goal of the current study is to perform an exploratory examination of possible associations between DBs and AD neuropathology in an initially cognitively intact community-based cohort.
methodsParticipants included in this study were ≥65 years of age, living independently, of average health for age, and followed until death. Algorithms, run on the continuously-collected passive sensor data, generated daily metrics for each DB: cognitive function, mobility, socialization, and sleep. Fixed postmortem brains were evaluated for neurofibrillary tangles (NFTs) and neuritic plaque (NP) pathology and staged by Braak and CERAD systems in the context of the "ABC" assessment of AD-associated changes.
resultsThe analysis included a total of 41 participants (M±SD age at death = 92.2±5.1 years). The four DBs showed consistent patterns relative to both Braak stage and NP score severity. Greater NP severity was correlated with the DB composite and reduced walking speed. Braak stage was associated with reduced computer use time and increased total time in bed. DISCUSSION: This study provides the first data showing correlations between DBs and neuropathological markers in an aging cohort. The findings suggest continuous, home-based DBs may hold potential to serve as behavioral proxies that index neurodegenerative processes.
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