ArticlePloS one2023
Bleb geometry and morphology after Preserflo Microshunt surgery: Risk factors for surgical failure.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Bleb characteristics following minimally invasive bleb surgeries in relation to surgical success using the anterior segment optical coherence tomography - a systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Pooled it
- Anterior Segment Optical Coherence Tomography and Anterior Segment Optical Coherence Tomography Angiography After Bleb Forming Glaucoma Surgeries: A Systematic Review.Clinical & experimental ophthalmology · 2025Pooled it
- Factors Associated with Favorable One-Year Outcomes After PreserFlo MicroShunt Implantation: Insights from Anterior Segment Optical Coherence Tomography.Advances in therapy · 2026Article
- Preoperative Surgical Site Vessel Density Is Predictive for Secondary Intervention after Preserflo Microshunt Implantation.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Structural anterior segment OCT biomarkers do not predict secondary intervention after Preserflo MicroShunt implantation.Frontiers in medicine · 2026Article
- Primary PreserFlo MicroShunt Versus Trabeculectomy: Effectiveness and Safety in the Real World.Journal of clinical medicine · 2025Article
- PRESERFLO™ MicroShunt as a treatment option for highly increased intraocular pressure in primary open angle glaucoma and pseudoexfoliation glaucoma.Eye (London, England) · 2025Article
- In vitro flow properties of Preserflo Michroshunt with an intraluminal stent.Eye (London, England) · 2025Article
- Management practices and surgical techniques for ab externo less invasive glaucoma surgery: a literature review and expert recommendations.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Factors Affecting Bleb Morphology and Postoperative Intraocular Pressure in Inferotemporal PreserFlo MicroShunt Implantation.Translational vision science & technology · 2025Article
- Postoperative Outcomes of PreserFlo MicroShunt in Patients with Exfoliation Glaucoma.Journal of clinical medicine · 2024Article
- Comparison of Bleb Morphology following PRESERFLODiagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the possible risk factors for treatment failure in patients who had undergone Preserflo Microshunt (PMS) implantation, using anterior-segment optical coherence tomography (AS-OCT) to analyze the internal structures of the bleb.
methodsThe PMS blebs of 54 patients were evaluated with AS-OCT. A mathematical model was used to calculate the total filtering surface of the episcleral fluid cavity (EFC) and the hydraulic conductivity (HC) of the bleb wall. Complete and qualified success were defined as IOP between 6 and 17 mmHg with or without glaucoma medication. The relation between baseline characteristics and probability of bleb success was analyzed by bivariate and multivariate logistic regression. The main outcome measures were mean bleb wall thickness (BWT), reflectivity (BWR), HC, mean horizontal and vertical diameter and total filtering surface (TFS) of the EFC.
resultsBlebs from 74% patients were considered as complete success and 26% as failure. BWR and BWT increased linearly up to the first year in both groups. BWR was higher in the group failure (p = 0.02) and BWT in the group success (p<0.001). EFC was wider and shorter in the success group (p = 0.009, p = 0.03). Higher TFS showed a negative correlation with IOP (r = -0.4, p = 0.002). Higher baseline IOP was associated with success of PMS by multivariate analysis (p = 0.01). Mean HC, 0.034 ± 0.008 (μL/min)/mm2/mmHg, was negatively correlated with bleb surface (r = -0.5, p<0.0001) and wall´s thickness (r = -0.3, p = 0.01).
conclusionsAS-OCT revealed that successful PMS blebs could show either thick hyporreflective walls or wide filtering surfaces with thin capsules. A higher baseline IOP increased the probability of surgical success.
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