Evidence map›Paper›PMID 37289556›Full record

ReviewAnnual review of biomedical engineering2023

Emerging Penetrating Neural Electrodes: In Pursuit of Large Scale and Longevity.

Lan Luan, Rongkang Yin, Hanlin Zhu, Chong Xie

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  7. Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lan LuanDepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, USA; email: lan.luan@rice.edu.
Rongkang YinDepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, USA; email: lan.luan@rice.edu.
Hanlin ZhuDepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, USA; email: lan.luan@rice.edu.
Chong XieDepartment of Electrical and Computer Engineering, Rice University, Houston, Texas, USA; email: lan.luan@rice.edu.
Rice University · US

Funding

Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordingsU01NS115588 · NINDS · RICE UNIVERSITY · PI FRANK, LOREN M, XIE, CHONG · 2020 to 2023
$4.6M
A Nanoelectronic Strategy for Reliable, Large-scale Chronic Neural RecordingR01NS102917 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI Chong Xie · 2017 to 2026
$3.5M
Longitudinal multimodal mapping to decipher the neurovascular impact of microinfarctsR01NS109361 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI LUAN, LAN · 2019 to 2023
$2.9M
Nanoelectronic enabled chronic quantification of neurovascular couplingK25HL140153 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI LUAN, LAN · 2018 to 2022
$890k
NHLBI NIH HHS K25 HL140153NINDS NIH HHS R01 NS102917NINDS NIH HHS R01 NS109361NINDS NIH HHS U01 NS115588
6 · The paper itself

Abstract

Penetrating neural electrodes provide a powerful approach to decipher brain circuitry by allowing for time-resolved electrical detections of individual action potentials. This unique capability has contributed tremendously to basic and translational neuroscience, enabling both fundamental understandings of brain functions and applications of human prosthetic devices that restore crucial sensations and movements. However, conventional approaches are limited by the scarce number of available sensing channels and compromised efficacy over long-term implantations. Recording longevity and scalability have become the most sought-after improvements in emerging technologies. In this review, we discuss the technological advances in the past 5-10 years that have enabled larger-scale, more detailed, and longer-lasting recordings of neural circuits at work than ever before. We present snapshots of the latest advances in penetration electrode technology, showcase their applications in animal models and humans, and outline the underlying design principles and considerations to fuel future technological development.

Indexed as

LongevityNeurosciencesAction PotentialsAnimalsBrainElectrodesElectrodes, ImplantedHumanschronicelectrophysiologylarge scalepenetrating electrodes

Identifiers

PMID37289556
PMCPMC11078330
OpenAlexW4379878391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.