Effects of caffeic acid phenethyl ester against multi-species cariogenic biofilms.

Xiaohui Lv, Zening Feng, Junyuan Luo, Zhenqi Liu, Junzhuo Lu, Sili Han, Kun Wang, Linglin Zhang

Abstract read

In one paragraph

Article in Folia microbiologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xiaohui LvState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China.

Zening FengState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China.

Junyuan LuoDepartment of Endodontics, College of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Zhenqi LiuState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China.

Junzhuo LuState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China.

Sili HanState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China.

Kun WangState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China. wangk0613@126.com.

Linglin ZhangState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Disease, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3 of Renmin Road South, Chengdu, 610041, China. zhll_sc@163.com.ORCID http://orcid.org/0000-0002-5003-5864

Sichuan University · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 81970931

6 · The paper itself

Abstract

Dental caries is a biofilm-related disease, widely perceived to be caused by oral ecological imbalance when cariogenic/aciduric bacteria obtain an ecological advantage. Compared with planktonic bacteria, dental plaques are difficult to remove under extracellular polymeric substance protection. In this study, the effect of caffeic acid phenethyl ester (CAPE) on a preformed cariogenic multi-species biofilm was evaluated, which was comprised of cariogenic bacteria (Streptococcus mutans), commensal bacteria (Streptococcus gordonii), and a pioneer colonizer (Actinomyces naeslundii). Our result revealed that treatment with 0.08 mg/mL CAPE reduced live S. mutans in the preformed multi-species biofilm while not significantly changing the quantification of live S. gordonii. CAPE significantly reduced the production of lactic acid, extracellular polysaccharide, and extracellular DNA and made the biofilm looser. Moreover, CAPE could promote the H

Indexed as

Dental CariesHydrogen PeroxideBiofilmsCaffeic AcidsExtracellular Polymeric Substance MatrixHumansPhenylethyl AlcoholStreptococcus mutanscaffeic acid phenethyl esterCaffeic AcidsHydrogen PeroxidePhenylethyl AlcoholAntibiofilmCaffeic acid phenethyl esterDental cariesMulti-species biofilmsStreptococcus mutans

Identifiers

PMID37289416

DOI10.1007/s12223-023-01064-w

OpenAlexW4379768512

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.