Evidence map›Paper›PMID 37289406›Full record

ArticleProbiotics and antimicrobial proteins2024

Hepatic Symbiotic Bacterium L. reuteri FLRE5K1 Inhibits the Development and Progression of Hepatocellular Carcinoma via Activating the IFN-γ/CXCL10/CXCR3 Pathway.

Nan Zhang, Shuiwen Ye, Xinlu Wang, Kang Wang, Fangmin Zhong, Fangyi Yao, Jing Liu, Bo Huang, Feng Xu, Xiaozhong Wang

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Role of CD4Cells · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nan ZhangJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Shuiwen YeDepartment of Blood Transfusion, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Xinlu WangJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Kang WangDepartment of Traditional Chinese Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Fangmin ZhongJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Fangyi YaoJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Jing LiuJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Bo HuangJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China.
Feng XuJiangxi-Oai Joint Research Institute, Nanchang University, Nanchang, 330047, Jiangxi, China. wangxiaozhong@ncu.edu.cn.
Xiaozhong WangJiangxi Province Key Laboratory of Laboratory Medicine, Department of Clinical Laboratory, the Second Affiliated Hospital of Nanchang University, Nanchang, 330047, Jiangxi, China. ziwu211@126.com.
Nanchang University · CNSecond Affiliated Hospital of Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Symbiotic bacteria participate in the formation of the structure and function of the tissues and organs in which they live, and play an essential role in maintaining the balance between health and disease. Lactobacillus reuteri FLRE5K1 was isolated from the liver of healthy mice and proved to be a probiotic with anti-melanoma activity in previous studies. The relationship between hepatic symbiotic probiotics and hepatocellular carcinoma (HCC) has not been reported yet. In the present study, L. reuteri FLRE5K1 was initially confirmed to successfully enter the liver after being administered by gavage, and the efficacy of probiotic feeding on HCC and its potential mechanism of inhibiting tumor progression were investigated by an orthotopic liver cancer model established. The results showed that L. reuteri FLRE5K1 significantly reduced the tumor formation rate and inhibited tumor growth in mice. From the perspective of mechanism, activation of the IFN-γ/CXCL10/CXCR3 pathway, as well as its positive feedback on the secretion of IFN-γ, induced the polarization of Th0 cell to Th1 cells and inhibited the differentiation of Tregs, which played a key role in the inhibitory effect of L. reuteri FLRE5K1 on the development and progression of HCC.

Indexed as

Carcinoma, HepatocellularChemokine CXCL10Interferon-gammaLimosilactobacillus reuteriLiver NeoplasmsProbioticsReceptors, CXCR3AnimalsHumansLiverMaleMiceMice, Inbred C57BLSignal TransductionSymbiosisChemokine CXCL10Cxcl10 protein, mouseCxcr3 protein, mouseInterferon-gammaReceptors, CXCR3Anti-cancer immunityHCCHepatic symbiotic probioticsIFN-γ/CXCL10/CXCR3 pathwayL. reuteri FLRE5K1

Identifiers

PMID37289406
OpenAlexW4379769588

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.