ArticleAging clinical and experimental research2023
Pan-immune inflammation value; a novel biomarker reflecting inflammation associated with frailty.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 36 citations in OpenAlex.
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- Incremental prognostic value of the systemic immune‑inflammation index, pan‑immune‑inflammation value, and modified glasgow prognostic score for severity assessment and outcome prediction in community‑acquired pneumonia.BMC pulmonary medicine · 2026Article
- Review
- A different perspective in trauma patients: can pan-immune-inflammation value (PIV) predict mortality?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- The effect of esketamine as adjuvant to ropivacaine for unilateral paravertebral block on postoperative pain and sensitization in adult patients undergoing video-assisted thoracoscopic surgery: a randomized clinical trial.Journal of anesthesia · 2026Article
- Pan-immune-inflammation value as a predictor of loss of ambulation in duchenne muscular dystrophy: a retrospective cohort study.BMC pediatrics · 2026Article
- Association Between the Frailty Index and Self-Reported Headache in Middle-Aged and Older Chinese Adults: An Analysis of the China Health and Retirement Longitudinal Study.Pain research & management · 2026Article
- Evaluation of ten composite inflammatory indicators for sarcopenia in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Pan immune inflammation value improves MELD 3.0 for mortality prediction in critically ill cirrhotic patients.Scientific reports · 2025Article
- Predictive utility of systemic inflammatory response index and pan-immune-inflammatory value in assessing myocardial infarction risk among cases with unstable angina.Scientific reports · 2025Article
- Evaluating the predictive value of systemic inflammation indices in early pregnancy loss: a retrospective observational study.BMC immunology · 2025Observational
- Exploring the impact of pan-immune-inflammation-value and other traditional inflammation-based markers on coronary collateral circulation in patients with chronic total occlusion.BMC cardiovascular disorders · 2025Article
- The correlation between systemic inflammatory index and rebleeding after bronchial artery embolization: a retrospective cohort study.International journal of emergency medicine · 2025Article
- Pan-Immune-Inflammatory value and risk of latent tuberculosis infection.Scientific reports · 2025Article
- Frailty and Cognitive Decline in Hospitalized Elderly Patients: Associations with Clinical and Laboratory Parameters.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Integrating pan-immune-inflammation value into personalized survival prediction of nasopharyngeal carcinoma: a large-scale long-term retrospective study.BMC cancer · 2025Article
- The role of inflammatory parameters in predicting acute complicated diverticulitis.Biomarkers in medicine · 2025Article
- Correlation between pan immune inflammation value and testosterone deficiency risk increase.Scientific reports · 2025Article
- The association between pan-immune-inflammation value with mortality in critically ill patients with sepsis-associated acute kidney injury.BMC infectious diseases · 2025Article
- Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention.Aging clinical and experimental research · 2025Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is suggested to be associated with age-related changes in the immune system, namely immunosenescence. Few studies have investigated the association of frailty with circulating immune biomarkers reflecting immunosenescence. Pan-immune inflammation value (PIV) is a new composite circulating immune biomarker to predict inflammation status.
aimThis study aimed to assess the relationship between PIV and frailty.
methodsA total of 405 geriatric patients were enrolled in the study. All participants underwent a comprehensive geriatric assessment. The comorbidity burden was evaluated with Charlson Comorbidity Index. Frailty status was evaluated via the Clinical Frailty Scale (CFS), and patients with CFS scores ≥ 5 were defined as living with frailty. PIV was calculated using the formula: (Neutrophil × monocyte × platelet)/lymphocyte. Patients were defined as PIV-low (≤ 372) and PIV-high (> 372).
resultsThe median age of participants was 72 (IQR = 67-78) years and; 63.0% (n = 225) were female. Patients were divided into two categories (i.e., robust and living with frailty groups), and 320 (79.0%) and 85 (21.0%) patients were in each group, respectively. Median PIV was higher in the living with frailty group (p = 0.008). In the linear and logistic regression analyses, both PIV and PIV-high (> 372) were significantly associated with frailty independently of confounders. DISCUSSION AND
conclusionThis is the first study revealing the relationship between PIV and frailty. PIV may be seen as a novel biomarker reflecting inflammation associated with frailty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.