ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023
Association of smoking with brain gray and white matter volume: a Mendelian randomization study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors.Translational psychiatry · 2025Article
- Cardiovascular risk factors modulate the effect of brain imaging-derived phenotypes on ischaemic stroke risk.Brain communications · 2025Article
- Alcohol, smoking, and brain structure: common or substance specific associations.medRxiv : the preprint server for health sciences · 2024Article
- Investigating the Relationship Between Smoking Behavior and Global Brain Volume.Biological psychiatry global open science · 2024Article
- Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies.Frontiers in neuroscience · 2024Review
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Authors and funding
3 authors.
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Abstract
backgroundObservational studies have found a significant association between smoking and smaller gray matter volume, but this finding was limited by the reverse causality bias and possible confounding factors. Therefore, we conducted a Mendelian randomization (MR) study to explore the causal association of smoking with brain gray and white matter volume from a genetic perspective, and to investigate the possible mediators influencing the association.
methodsSmoking initiation (ever being a regular smoker) was used as the primary exposure from the GWAS & Sequencing Consortium of Alcohol and Nicotine use in up to 1,232,091 individuals of European descent. Their associations with brain volume were acquired from a recent genome-wide association study of brain imaging phenotypes conducted among 34,298 individuals of the UK Biobank. The random-effects inverse-variance weighted method was applied as the main analysis. Multivariable MR analysis was performed to assess the potential interference of confounding factors on causal effect.
resultsGenetic liability to smoking initiation was significantly associated with lower gray matter volume (beta, -0.100; 95% CI, -0.156 to -0.043; P=5.23×10
conclusionsThis MR study supports the association between smoking and lower gray matter volume, and highlights the importance of never smoking.
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